autophagy

autophagy

1. Anderson team shows in lab experiments that inhibiting the protein in pancreatic cancer cells leads to a form of programmed cell suicide called autophagy, or self-digestion.

Anderson研究组成员的实验证实了：抑制胰腺癌细胞中TG2蛋白能导致细胞的程序化死亡，被称为自噬或者自我消化。

2. An Armed Oncolytic Adenovirus System, ZD55-Gene, Demonstrating Potent Antitumoral Efficacy 2.Resveratrol Induces Autophagy in BEL7404 Human Hepatoma Cells by Upregulation of Beclin 1

一.携带治疗基因的肿瘤特异性增殖腺病毒ZD55-Gene治疗肿瘤 二.白藜芦醇诱导细胞自噬性死亡及分子机制

3. Expression and Involved Signal Transduction Pathway of Autophagy Gene Beclin 1 in Epithelial Ovarian Cancer

上皮性卵巢癌中自噬基因Beclin 1的表达及其调控相关信号传导途径的研究

4. Future studies will determine whether and how manipulation of the autophagy pathway improves post-TBI recovery.

今后的研究将决定自噬途径是否及如何操控外伤性脑损伤后的恢复改善。

5. Deretic is fascinated with autophagy both as a fundamental biological process and as an effector of innate and adaptive immunity.

他醉心于细胞自噬的研究，包括基本的生物作用与影响先天性和适应性免疫反应的部份。

6. chaprone-mediated autophagy pathway

伴侣自吞噬

7. As part of this work, several recent studies have focused on autophagy in heart disease elicited by changes in hemodynamic load.

作为这项工作的一部分，几项近来的研究集中于通过改变血流动力学负荷来引出自溶作用在心脏病中作用。

8. Keywords Endometrioid adenocarcinoma;Autophagy;LC3;Cathepsin D;

关键词子宫内膜样腺癌;自噬;LC3;组织蛋白酶D;

9. Keywords Aminophylline;Dexamethasone;T lymphocytes;Autophagy;Apoptosis;

关键词氨茶碱;地塞米松;T淋巴细胞;自噬;凋亡;

10. Keywords axon;autophagy;nerve regeneration;

关键词轴突;自噬;神经再生;

11. Among them, only apoptosis and autophagy are well known.

其中研究最为清楚的是细胞凋亡和自噬两种方式。

12. Keywords concanavalin A;macrophages;receptor-mediated endocytosis;autophagy;apoptosis;

刀豆素A;巨噬细胞;受体介导内吞;自噬;凋亡;

13. Similarly, clonidine, currently used to treat hypertension or migraine, appears to work on autophagy by decreasing levels of cAMP, a molecule that is important in many biological processes.

剑桥大学的科学家们已经确立许多候选药物作为进一步研究以发现哪种机制促使细胞吞噬导致这种疾病的畸形蛋白分子。

14. Therefore,activation of the autophagy pathway may play a key role in removing damaged cellular componentsafter TBI.

因此，自噬途径的激活可能会在TBI之后清除受损细胞扮演着关键角色。

15. Induction of autophagy after TBI may be responsible for eliminating aberrant cellular components, thus maintaining cellular homeostasis after TBI.

在TBI发生后,细胞的自噬可能起了消除细胞中的异常成分,同时保持细胞中物质动态平衡的作用。

16. In tumour cells with defects in apoptosis, autophagy allows prolonged survival.

在凋亡缺陷的肿瘤细胞中，自噬延长了生存期。

17. Autophagy is, in part, a cleanup process: the trash hauling that enables a cell whose cytoplasm is clotted with old bits of protein and other unwanted sludge to be cleaned out.

在某种程度上，细胞自噬是个扫除过程：搬走垃圾，并清理细胞质中纠结的老旧蛋白质和其他无用废物。

18. Three of the molecules that enhanced the growth-suppressing effects of rapamycin in yeast were also found to induce autophagy by themseles in mammalian cells independent of the action of rapamycin.

在酵母中三个分子可以增强雷帕霉素对酵母的生长抑制，他们三个分子都可以诱导哺乳动物细胞自我吞噬，且不依赖于雷帕霉素。

19. Morphological observation of Schwann cell autophagy during regenerative course of sciatic nerve

坐骨神经再生过程中施万细胞自噬的形态学观察

20. Variety of Gene Expression Profiles in Autophagy and Apoptosis

基因芯片检测自噬与凋亡的基因表达谱改变

21. The research of autophagy has revealed the effect of autophagy on carcinogenesis and provides us a promising avenue for cancer therapy and prevention.

对于自噬作用的研究进一步揭示了肿瘤发生、发展的潜在机制，也为肿瘤的治疗和预防提供了新的思路。

22. Autophagy is a fail-safe against such a destructive mistake.

对于这种破坏而造成的错误，自噬作用称得上是保全系统。

23. It has been known for some time that autophagy is active in cardiomyocytes, occurring at increased levels in disease.

已知某些时候自噬细胞在心肌病中激活，在疾病中增多。

24. Bency: In this experiment, it's the first time to clarify rapamycin-induced protective effect that is not dependent on autophagy, the main mechanism may work through the activation of PI3K-AKT way.

想表达的意思：本实验第一次阐明雷帕霉素诱导的保护作用不依赖于自噬，它起作用的主要机制可能是通过激活PI3K-AKT途径。

25. Here we show that a primary small-molecule screen in yeast yields novel small-molecule modulators of mammalian autophagy.

我们发现了第一个进入酵母的小分子，产生了新的小分子调节恒温动物的自我吞噬作用。

26. Inhibition of phosphoinositide 3-kinase preserved cardiac function and attenuated expression of the senescence markers associated with enhanced autophagy.

抑制性磷酸肌醇-3激酶抑制心脏功能，减弱了衰老标记物的表达，而衰老标记物与提高自我吞噬功能相关。

27. Many anticancer drugs can activate autophagy in cancer cells and participate in the molecular regulation of autophagy.

抗肿瘤药物可以诱导细胞产生自噬,并参与了自噬的分子调控,同时它也可能导致细胞凋亡。

28. Many anticancer drugs can activate autophagy in cancer cells and participate in the molecular regulation of autophagy.These drugs also induces apoptosis of cancer cells.

抗肿瘤药物可以诱导细胞产生自噬，并参与了自噬的分子调控，同时它也可能导致细胞凋亡。

29. Autophagy is a ubiquitous physiological process that occurs in all eukaryotic cells.It can be induced by starvation, ischemia/reperfusion injury and heart failure.

摘要自噬是一种广泛存在于真核细胞中的生命现象，心肌细胞营养缺乏、缺血／再灌注损伤、心衰等均可诱发细胞自噬。

30. Autophagy is a process in which the subcellular membrane structures undergo dynamic morphological changes that lead to degradation of cellular proteins and organelles by lysosomes.

摘要自噬是亚细胞膜结构发生动态变化并经溶酶体介导对细胞内蛋白质和细胞器降解的过程。

31. Keywords Schwann cells;autophagy nerve regeneration Wallerian;

施万细胞;自噬;神经再生;

32. Remarkably, autophagy may also play a role in determining the human life span.

显然，自噬作用在决定人类的寿命上，可能扮演重要角色。

33. In this review we introduce the pathogenesis of neural degeneration diseases, the mechanism of autophagy and the effect on neural degeneration diseases.

本文对神经退行性疾病的发病机理，细胞自噬的机理以及对神经退行性疾病的作用进行了综述。

34. This review focuses on the processes of autophagy and its roles in cell survival and cell death.

本文对自噬的过程及其在细胞存活和死亡中的作用作一综述。

35. This study shows that the autophagy pathway is markedly changed in vulnerable brain regions after TBI.

本研究显示，自噬途径在外伤性脑损伤的后的脑受伤区域内有明显的变化。

36. Kroemer G, Jaattela M. Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005,5:886-897.

溶酶体水解酶释放入胞外参与肿瘤过程。在肿瘤细胞中有溶酶体变化。自体吞噬小泡也与肿瘤发生相关。

37. Keywords OsPDCD5;OsCIPK23;OsAtg8;OsAtg4;glycin;rice;programmed cell death;autophagy;

甘氨酸;水稻;程序性细胞死亡;自噬;

38. glucagon treatment of liver leads to increased autophagy

用高血糖素处理肝脏，会导制自噬作用增加。

39. Objective To study the exist of Taxol-induced autophagy and autophagic cell death in SGC-7901/BGC-823 cell lines, and to study the role to the sensibility of apoptosis induced by Taxol.

目的明确自噬和自噬性细胞死亡在胃癌SGC-7901及BGC-823细胞紫杉醇处理过程中的存在,探讨其对紫杉醇诱导的凋亡敏感性的作用。

40. Objective To observe the effects of aminophylline on autophagy and apoptosis in spleen T lymphocytes of mouse.

目的观察氨茶碱对正常小鼠脾T淋巴细胞自噬及凋亡的调控作用。

41. Autophagy in Fungi and Mammals

真菌和哺乳动物中的自噬

42. Mitochondrial autophagy

线粒体自噬

43. Cells with signs compatible with both apoptosis and autophagy were observed.

细胞同时用凋亡和自噬标志进行观察。

44. cellular autophagy

细胞自体吞噬

45. Autophagy also plays an important role in virus replication.

细胞自噬也在病毒复制方面扮演了重要角色。

46. Autophagy and its role in carcinogenesis

细胞自噬及其在肿瘤发生过程中的作用

47. Cytoplasmic components may well be scavenged by selective autophagy.

细胞质的组分能通过选择性的自噬作用被摄

48. Moreover, knockdown of SGLT1 directly mimicked EGFR siRNA-mediated autophagy.

而且，沉默SGLT1能直接模拟EGFRsiRNA介导的自噬性细胞死亡。

49. A breakdown in the autophagy system in brain neurons has been linked to Alzheimer's disease, as well as to aging itself.

而大脑神经元的自噬功能衰退，即和阿兹海默症及老化有关。

50. 7. Autophagy, appears to involve an active participation of the vacuolar membranes.

自体吞噬似乎与液泡膜的积极参加有关。

51. Autophagy The process by which worn-out cell organelles are enclosed in vacuoles, then broken down by hydrolytic enzymes secreted into vacuole, the breakdown products being reabsorbed afterward.

自体吞噬：老化或废弃的细胞产生自体吞噬泡，然后与溶酶体融合进行消化降解的过程。溶酶体产生的水解酶分解已经老化的细胞。

52. Autophagy is affected by many factors and modulated by a series of signaling molecules,which result in different molecular reactions and different sequels.

自吞噬的过程受许多因素的影响,并受一系列复杂的信号分子调控,由此引起不同的分子效应,最终导致细胞走向不同的结局。

53. Keywords autophagy;CD4+ T lymphocyte;asthma;dexamethasone（DXM）;

自噬;CD4+T淋巴细胞;哮喘;地塞米松;

54. Keywords autophagy;apoptosis;cell survival;cell death;

自噬;凋亡;细胞存活;细胞死亡;

55. Keywords autophagy;lysosome;quinolinic acid;NMDA receptors;excitotoxicity;

自噬;溶酶体;喹啉酸;NMDA受体;兴奋性毒性;

56. Keywords autophagy;autophagosome;lysosome;signaling transduction;

自噬;自噬体;溶酶体;信号转导;

57. Keywords autophagy;inductive mechanisms;cancer therapy;

自噬;诱导机制;肿瘤治疗;

58. There is a close relationship between autophagy and apoptosis during cell death.

自噬与凋亡在细胞死亡过程中的关系十分密切。

59. Autophagy is a cellular process that enables cells to turnoer their contents, something that they do frequently.

自噬作用是一种细胞过程，该过程是细胞经常性的转移细胞内容物的一种方式。

60. Autophagy and Its Roles Played on Cell Metabolism and Diseases

自噬及其在细胞代谢和疾病中的作用

61. The actual role of autophagy in antitumor effects of these drugs, however, depends on concentrations of drugs and the types of tumor cells.

自噬在抗肿瘤药物中作用与给药浓度及细胞的类型等因素有关。

62. Bioinformatics Analysis of Autophagy 5 Gene Structure

自噬基因APG5基因结构的生物信息学分析

63. Autophagy exists but is disrupted because the immaturity of autophagic vacuoles leads to the failure of autophagy circulation.

自噬既有发生又有被破坏, 其破坏的主要原因是自噬小泡的不成熟导致自噬不能有效循环。

64. Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles.

自噬是一个为了清除损伤或多余蛋白和细胞器的细胞降解通路。

65. Autophagy is an adaptive response of cells to physiological and pathological conditions.

自噬是一种在正常细胞和病态细胞中普遍存在的生理机制。

66. Autophagy is a vacuolar process of cytoplasmic degradation by lysosome.

自噬是以细胞质空泡化为特征的溶酶体依赖性的降解途径。

67. Autophagy occurs in all types of eukaryotic cells, which has a rigid connection with the normal or abnormal development of cells and is associated with many diseases.

自噬是广泛存在于真核细胞中的生命现象,它与细胞的正常生长发育进程以及多种疾病的发生发展密切联系。

68. There are three basic types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy.

自噬有三种类型:大自噬,小自噬和分子伴侣介导的自噬。

69. Autophagy kills by degrading those other organelles while sparing the nucleus.

自噬消化的是除胞核外的其他细胞器。

70. The role of autophagy in pharmacological actions of anticancer drugs

自噬激活与抗肿瘤药物的作用

71. When autophagy occurs, a double membrane forms around a cell organ, or organelle.

自噬现象出现时，会在细胞或细胞器的周围形成双层膜。

72. Molecular mechanism of autophagy associated with diseases

自噬的分子机制与病理生理意义

73. Inhibition of autophagy influences the autophagic apoptosis induced by vincristine

自噬的抑制影响长春新碱诱导的肝癌细胞自噬性凋亡

74. The process is controlled by complex signalling pathways.Irregulation of autophagy is associated with such as several diseased states cancer,neurodegenerative diseases,and aging.

自噬的过程受一系列复杂的信号分子的调控,调控机制的失效与肿瘤、神经退行性疾病、衰老等有重要的联系。

75. The autophagy pathway is the chief route for bulk degradation of damaged cell membranes, neuronal processes, and organelles after TBI.

自噬路径是TBI之后，大量受损细胞膜和细胞器官降解的主要途径。

76. Paradoxically, autophagy defects are associated with increased tumorigenesis, but the mechanism behind this has not been determined.

自相矛盾的是，自噬缺陷与肿瘤发生的呈正相关，但这背后的机制仍没有被明确。

77. Besides,it is closely related to the autophagy,mitochondrial apoptotic pathways,and changes of endogenous and exogenous factors.

致病真菌的凋亡与真菌的自体吞噬、线粒体凋亡通路、内源性和外源性因素的变化等密切相关。

78. They exhibit autophagy with a reduction in the number of cell organells, and often a marked increase in the number of autophagic vacuoles.

萎缩细胞发生自噬；其细胞器数量减少，自噬泡常明显增多。

79. Although the research towards autophagy was on its initial step,it has been proven that autophagy and apoptosis together regulate cell aging and cell death.

虽然对自吞噬研究的时间并不长,但已证实自吞噬与凋亡一同调节细胞的衰老和死亡。

80. The target of rapamycin proteins regulate various cellular processes including autophagy, which may play a protective role in certain neurodegenerative and infectious diseases.

蛋白的靶点调节各种细胞代谢过程,包括自我吞噬,这在某些神经变性病中可能起保护性的作用。