azt

azt

1. "The cumulatie mutagenesis data suggest that infants exposed transplacentally to AZT may be at increased risk for cancer as they age," researchers said in a statement.

"积累的遗传突变数据指出婴儿经胎盘被传递给了AZT,随着他们年龄的增长可能会提高患癌症的风险",研究者在陈述中指出.

2. In 1987, William the first to introduce Glaxo zidovudine (AZT), and by the U.S.Food and Drug Administration approval to become the first application of the material Kangai Yao.

1987年，葛兰素威廉率先推出齐多夫定（AZT），并获美国食品与药品管理局的批准，成为最先应用的抗艾药物。

3. In August 2002, we had the domestically manufactured ARV drug, AZT, produced by Northeast Pharmaceuticals.

2002年8月，国产的第一个抗病毒药品齐多夫定在东北制药总厂被批准生产。

4. 3) to be treated with 0.8 mm/L AZT for 24 h;

3)加药组:细胞培养液中加入终浓度为0·8mmol/L的AZT作用24h;

5. 3'-Azido-deoxythymidine (AZT)

3＇-叠氮脱氧胸苷

6. Higher concentration of AZT in mice injected AZT-GalCer was found in plasma after 30 min and it was ten times as high as in mice injected with AZT.

AZT GalCer组较游离AZT组血药浓度显著升高 ,特别是 30min后升高达数十倍 ;

7. The inhibition effect on cancer cell line HO-8910 of AZT combined with adriamycin, carboplatin was stronger than that of single-drug group (P<0.01).

AZT与卡铂、阿霉素联合用药对细胞抑制作用明显增强,与AZT、卡铂、阿霉素单独用药组相比差异有显著性(P<0.01)。

8. Telomerase activity of HO-8910 cells was significantly inhibited when treated with AZT, and cell cycle of treated HO-8910 cells was changed with marked increase in G 2/M phase.

AZT作用后的 HO-8910细胞端粒酶活性明显受抑制 ,且细胞的 G2 /M期 DNA含量明显增高 .

9. AZT can inhibit the telomerase activity and induce apoptosis of SMMC-7721 cells, which is related to specific small molecular proteins.

AZT可抑制SMMC-7721细胞端粒酶活性,诱导凋亡与相关特异小分子蛋白有关。

10. AZT inhibited growth of HO 8910 cell and the effect was in a time dependent manner and dose dependent manner.

AZT对 HO-8910细胞的生长有抑制作用 ,并有时间依赖关系和剂量依赖关系 .

11. Study on the Expression of Bax and PCNA and Their Relations with Apoptosis Induced by AZT on Implanted Liver Cancer in Rats

AZT对大鼠种植性肝癌细胞凋亡及bax蛋白和PCNA表达影响的研究

12. AZT leading to anemia has no regular rules.

AZT导致的贫血有时候真的是缺乏固定的规律。

13. The optimized treatment time of AZT was 48 h, and the optimized concentration of AZT was 20 mmol/L.

AZT抑制癌细胞生长的最佳作用时间为48h,最佳作用浓度为20mmol/L;

14. Azt measurement

Azt测量

15. The role of AZT radiosensitization mechanisms may be related with its role of DNA DSB repair.

AZT的放射增敏作用机制与其对DNA DSB的修复有关。

16. The results indicate that AZT can effectively inhibit telomerase activity of U251 glioma cells treated or untreated with 2 Gy radiation and significantly enhance the radiosensitivity of U251 glioma cells in vitro .

AZT能明显抑制 2Gy照射诱导的U2 5 1细胞端粒酶活性升高 ,并显著增加U2 5 1细胞的放射敏感性 ;

17. ZIDOVUDINE (Systemic) zai'd4uvjudi:n Another commonly used name is AZT ." Antiviral (systemic).

n"叠氮胸苷,齐多夫定,叠氮脱氧胸苷"""

18. an antiviral drug that inhibits replication of the retrovirus that causes AIDS; AZT

一种可抑制导致爱滋病病毒的复制的抗病药物；叠氮胸苷

19. Compared with the control, addition of AZT inhibited telomerase activity and cell proliferation in time-dependent (12 h vs. 24 h) and dose-dependent (0.5 mol/L vs. 1.0 mol/L) manners (P<0.05-0.01).

与对照组比较,12h后1.0molLAZT组的端粒酶活性降低(P<0.05),24h时0.5molLAZT组细胞生长增殖受抑制(P<0.05),1.0molLAZT组则呈现出显著性差异(P<0.01),在实验范围内,呈时间-剂量依赖性。

20. In addition,the concentrationaveraged overall drug targeting efficiency(r_e) of the liver presented by AZTP CL and GalLs containing 3%,5%,10%(mol/mol) CH-ED-LA increased 1.32 and 1.48,2.13,1.50 times as that of AZT solution,respectively.

与齐多夫定溶液剂相比,齐多夫定棕榈酸酯普通脂质体和CH-ED-LA分别占脂质总量3%,5%,10%(mol/mol)的半乳糖化脂质体的药物肝靶向摄取率(re)分别为1.32和1.48,2.13和1.50。

21. Study of HIV-1 Resistant to AZT Virus Strain in Vitro

人免疫缺陷病毒I型抗AZT抗药株的体外研究

22. He told them that he wanted AZT, a drug used to treat AIDS patients, to be given to HIV-positive pregnant women to prevent the disease being passed on to their unman babies .

他告诉他们他想要爱滋病防护药提供给带有爱滋病毒的孕妇们，以预防疾病传染给她们虚弱的婴儿们，这是一种为爱滋病患者提供治疗的药。

23. AZT can cause severe side effects, such as anemia.

但AZT会引发严重的副作用，像是贫血。

24. However, the GSK spokeswoman said that US Court of Appeals for the Federal Circuit has long reviewed the patent right of AZT and ruled the validity of this patent.

但葛兰素公司女发言人说，美国联邦巡回法庭上诉法院早已检测过AZT的专利权，并裁定此一专利权有效。

25. Zidovudine (AZT)

依非韦伦（EFV）

26. Keywords Dysosma versipellis;chemical compositions;AZT;IFG;pharmacology;

八角莲;化学成分;叠氮胸苷;IFG;药理学;

27. Keywords HIV;Nucleoside reverse transcriptase inhibitors （NRTIs）;Azidothymidine （AZT）;PEG;Modify;Pharmacokinetics;Tissue distributions;

关键词HIV;核苷类逆转录酶抑制剂;齐多夫定;聚乙二醇;修饰;药物动力学;组织分布;

28. One of these studies has found that of the ten licensed compounds tested, only AZT inhibited replication of XMRV.

其中一个研究已发现在十个已测的得到批准的混合物中，只有AZT（艾滋病防护药）抑制了XMRV的繁殖。

29. Typically, neirapine is gien in combination with AZT and lamiudine.

典型三联用药：奈韦拉平联合AZT和拉米夫定。

30. Functional images are from two time points, before and after therapy with AZT.

功能性成像摄自艾滋病防护药治疗前和治疗后两个时间点。

31. AZT group:adding the final concentration of 0.8 mm/L AZT in the cell culture fluid in 24 h.

加药组:细胞培养液中加入终浓度为0.8 mm/L的AZT,作用24 h;

32. As a result,the optimum directing substracts are FEP,CTX,AZT and CRO,the best distance is 15 mm.

双纸片协同实验中检出率高的底物为FEP、CTX、AZT、CRO,其最佳协同距离为15 mm。

33. R-HPLC determination of plasma AZT concentration

反相高效液相色谱法检测齐多夫啶的血药浓度

34. An antiviral drug that inhibits replication of the retrovirus that causes AIDS; AZT.

叠氮胸苷一种可抑制导致爱滋病病毒的复制的抗病药物；叠氮胸苷

35. Effects of AZT on the Repair of DNA Double-strand Breaks of Human Malignant Glioma Cells after Radiation

叠氮胸苷对人胶质瘤细胞辐射后DNA双链损伤修复的影响

36. Study on Bio-Activity and Metabolism of Polysaccharide Sulfates-Containing AZT in Animal Body

含AZT硫酸化多糖的动物体内活性及代谢研究

37. Maybe, enhancing tests are able to the only way (especially stopping AZT), and find out those particular patients in time.

唯一的办法也许就是加强检测（特别是包括停用AZT以后），及时发现那些特殊的病人。

38. At the distance of 20 mm,the detection rate of FEP,CTX and AZT disks are all 88%,the detection rate of CRO disk is 75%.

在20 mm处FEP、CTX、AZT检出率为88%,CRO检出率为75%。

39. In EIAV-DEDLC system, the anti-EIAV efficacies of AZT, Ribavirin and PFA were determined by means of BA staining method.

在马传染性贫血病毒-驴胚肺二倍体细胞(EIAV-DELDC)系统中,采用直接生物素抗生物素(BA)染色法,测定了叠氮胸苷(AZT)、三氮唑核苷(Ribavirin)和磷羟基甲酸钠(PFA)三种药物抗EIAV作用。

40. After treatment with AZT, the telomerase activity in SMMC-7721 cells was detected by real-time fluorescent quantitative TRAP (FQ-TRAP) assay;

实时荧光定量端粒重复序列扩增法(real-timefluorescentquantitativeTRAPassay,FQ-TRAP法)检测AZT作用后,SMMC-7721细胞端粒酶活性变化;

41. Even so,they are often given AZT,a drug believed to lengthen the lives of those with full-blown AIDS.

尽管如此，他们往往还是会接受AZT治疗，一般相信这种药物可以延长艾滋病发病者的生命。

42. no attacker can go through enough trash to find every AZT user in the country.

我想任何一个攻击者都无法找出美国所有的AZT用户。

43. Objective To improve diagnostic level of rare cases during antiretroviral therapy, we analyze the clinical and laboratory characters of dilated cardiomyopathy caused by AZT.

摘要目的为了提高艾滋病抗病毒治疗过程中罕见病例的诊断水平，本文分析了齐多夫定(AZT)所致心肌病的临床和实验室检查特点。

44. Methods:MMF was administered in group A,and AZT in group B.Prednisone was administered in both groups.

方法 :A组服用MMF ,B组服用硫唑嘌呤。 2组均服强的松。

45. Methods The mice were injected to produce the animal model of lymphoma and then were divided into four groups:untreated group,radiative treated group,AZT treated group and radiation +AZT group.

方法采用小鼠为实验动物,复制小鼠淋巴瘤实验模型,随机分为未治疗组单纯放疗组、单纯AZT组和放疗加AZT组,观察各组的治疗效果。

46. The oldest AIDS drugs, such as AZT, block a stage of this copying process.

最古老的AIDS药物AZT就是阻止了这个复制过程。

47. The telomerase activity (A 450 nm) of marrow cells was 1.498, 1.483, 0.816 and 0.727 in untreated, irradiation, lamivudine and AZT groups, respectively.

未处理 ,单纯X线照射 ,单纯lamivudine和单纯AZT处理的小鼠骨髓细胞端粒酶活性分别为 1.4 98,1.4 83,0 .816和 0 72 7,AZT和lamivudine均有减少骨髓细胞端粒酶活性的作用 (P <0 .0 5 )。

48. The peripheral WBC increased 3.7% in untreated mice, and irradiation, lamivudine and AZT reduced 18.09%, 16.19% and 41.00% of WBC, respectively (P<0.05) .

未处理小组小鼠外周血白细胞升高 3.70% ,单纯X线照射 ,单纯lamivudine和单纯AZT处理的小鼠外周血白细胞下降率分别为 18.0 9% ,16 .19%和 4 1.0 0% ;

49. The tumor size of mice increased 3.3 times in untreated group. AZT, radiotherapy and AZT combined with radiotherapy reduced tumor volume of 26.3%,36.8% and 70.5%.

未治疗组小鼠肿瘤体积增加了 2 .5倍 ,而 AZT组、放疗组及 AZT联合放疗组肿瘤体积分别缩小了 2 6 .3%、36 .8%及 70 .5%。

50. In addition, both AZT and AS_ONS can induce apoptosis and arrest G-1 phase of cell cycle.

此外 ,AS_ONS和AZT还有诱导细胞凋亡以及使细胞阻滞在G1 期的作用。

51. After treatment, CD4 and CD4/CD8 increased, better than that of AZT.

治疗后，CD4细胞数及CD4/CD8比值均有回升，较AZT组为优。

52. Starch containing AZT was obtained by reaction of 5--Sue-AZT and water-soluble starch in DMSO, catalyzed by DMAP and N,N -dicyclohexylcarbodiimide (DCC). Aftersulfated by SO3 ?

然后以DMAP和N，N-dicyclohexylcarbodiimide(DCC)为催化剂，在DMSO中将5’-Suc-AZT与水溶性淀粉反应，得到含AZT的淀粉多糖；

53. AHF said that it will sue for damages caused by GSK's artificially inflated prices on such drugs as AZT, Ziagen and 3TC

爱滋病保健基金会说，它要控告葛兰素制药厂人为哄抬AZT、Ziagen以及3TC等药物价格造成该基金会蒙受损失。

54. Using confocal microscope, the lymphocytic nucleus of ZY-1 group revealed better repairing than AZT;

用共聚焦显微镜作病理形态学观察，可以看到，ZY－1组与AZT组比较，淋巴细胞核有明显修复。

55. The synergism of AZT combined with FLX was studied by using microbiologic method and SEM.

用细菌学方法、扫描电镜的方法考察AZT对FLX的体内增效作用。

56. Since his WBC was around 3.0 X 109/L, (3000/ul), AZT changed to saquinavir 600mg Bid, TMPco#2 qd, DDC 0.75rag Bid. He was still followed in OPD (outpatient department).

由于白细胞一直在3.O×109/L(3,000/u1),故将AZT改用Saquinavir600mg1天2次,TMPco2片l天1次,双脱氧胞苷(DDC)0.75ragl天2次,目前仍在门诊随诊。

57. The patient showed that tetter didn't appear today after taking twice AZT.

病人来电话告知，今天服用两次AZT目前无皮疹出现。

58. Pathologic examination:lymph follicle and germinal center activated, while in AZT group showed depletion.

病理学检查，ZY－1组淋巴滤泡和生发中心呈激活状态，为淋巴滤泡增生阶段，而AZT组则滤泡消失，组织萎缩，出现耗竭现象。

59. Effects of intratumoral injection of telomerase inhibitor AZT on implanted liver cancer in rats

瘤内注射端粒酶抑制剂AZT对大鼠种植性肝癌的影响

60. Res. in combination with AZT and 3Tc is able to reduce WBC count(83.34%),splenomegaly(91.70%),and upgrade CD_4~+/CD_8~+ values.

白藜芦醇和AZT3、Tc的联合用药有较好的抗病毒效果(减少白细胞数83.34%,脾肿抑制率91.79%,升高CD4+/CD8+比值等)。

61. To compare the effects of treatment methods between Mycophenolate mofetil(MMF)and azathioprine(AZT)combined with prednisone respectively in treating HBV_GN.

目的 :对比霉酚酸酯 (MMF)联合强的松与硫唑嘌呤联合强的松治疗乙肝病毒相关性肾炎 (HBV_GN)的疗效。

62. Objective To study effects of free and GalCer liposome-encapsulated azidothymidine(AZT) and foscarnet(PFA) on HIV-1 infectivity.

目的 研究体外空白及包封抗HIV药物AZT和PFA 的GalCer脂质体 对HIV-1复制的影响。

63. Objective To observe the effect of radiation and telomerase inhibitor(AZT) on the treatment of mouse lymphoma.

目的观察放射治疗联合端粒酶抑制剂(AZT)对小鼠淋巴瘤的治疗效果。

64. AZT inhibit telomerase activity of squamous cell carcinoma of tongue

端粒酶抑制剂对舌癌细胞株端粒酶活性和细胞周期的作用

65. The first drug approved for use against HIV, zidovudine (AZT), is a nucleoside analogue as well.

第一个上市对抗HIV的药物是叠氮胸苷（AZT），也是核苷的类似物。

66. Anti--AZT Toxic Effect of Acanthopanax Giraldii Polysaccharide(AGPS) on Hematopoiesis and Immune Function in Mice

红毛五加多糖对抗AZT抑制小鼠造血功能和免疫反应的药理实验研究

67. Johnson acknowledged that he has in the past taken AZT, the antiviral drug typically administered when a person's helper T-cell count drops to 500.

约翰逊承认他曾服用AZT，这种药物一般开给体内辅助性T细胞数量少于500的人服用。

68. 7.RESULTS AZT inhibited growth of HO 8910 cell and the effect was in a time dependent manner and dose dependent manner.

结果AZT对HO-8910细胞的生长有抑制作用,并有时间依赖关系和剂量依赖关系.

69. Results The patient had heart failure symptoms.Imagine examinations showed findings of dilated cardiomyopathy.The myocardiopahy of this patient was caused by AZT.

结果病人出现心衰症状，影像学检查见扩张性心肌病表现，综合分析认为，心肌病由AZT导致。

70. Much higher concentration of AZT in mice injected AZT-GalCer were found in plasma after 30min and it was ten times as high as in mice injected with AZT.

结果，AZT-GalCer组较F-AZT组血药浓度显著升高，特别是30min后升高达数十倍；

71. Conclusion Self-assemblies of AZT lipid prodrugs degrade into AZT rapidly in rat plasma.

结论 齐多夫定脂质前药自组装体在体外生物环境中能较快地降解出原药。

72. Conclusions AZT is a kind of drugs which can cause myocardiopathy.Though this adverse event is rare, we should keep an eye out for it.

结论AZT是引起扩张性心肌病的药物之一，尽管这一不良反应的发生较为罕见，但在临床工作中也应警惕。

73. Nevertheless radiation group and AZT combined with radiation group all show up obvious comet figure,the incipient DSB of AZT combined with radiation group compared with radiation group is not significant difference(P>0.05).

而放射组和药放组均出现明显的彗星图象,药放组的初始DSB与放射组相比无显著性差异(P>0.05)。

74. The relative telomerase activity in untreated group was 100, 52.6 in AZT, 23.3 in radiotherapy, and 10.4 in AZT combined with radiotherapy group.

肿瘤端粒酶活性检测 ,未治疗组、AZT、放疗及AZT联合放疗组的相对端粒酶活性分别为 10 0 ,5 2 .6 ,2 3.3及 10 .4。

75. The relative telomerase activity was 100 in untreated group,55.2 in AZT, 24.5 in radiotherapy, and 12.1 in AZT combined with radiotherapy group.

肿瘤端粒酶活性检测 ,未治疗组、AZT组、放疗组及 AZT联合放疗组的相对端粒酶活性分别为 10 0、5 5 .2、2 4 .5及 12 .1。

76. AZT capsules

艾滋特胶囊

77. Keywords AZT;mathematic model;predict analysis;

艾滋病;数学模型;预测分析;

78. On the other hand, Ke decreased significantly from 0.037 to 0.021 h -1 , T_ 1/2 Ke increased significantly from 19 min to 35 min, and AUC was 2.77 times as high as in mice injected with AZT.

药物的Ke由 0 0 37h-1降至 0 0 2 1h-1,T1/2 由 19min延长至 35min ,AUC增加 2 .77倍。

79. The detection rates of FEP,CTX,AZT and CRO disks are all 100% when the distance between the two disks is 15 mm.

试验结果表明:FEP、CTX、AZT、CRO在15 mm处检出率均为100%;

80. TMPco was adjusted to 2 Bid. Shortness of Breath and general condition were improved. He was given AZT 100mg Bid, TMPco 2 Bid, Until Dec. 18, 1997 his Body weight increased from 72kg to 88kg, he went Back to work as usual.

调整TMPc02片日2次,患者一般情况和气短明显好转。患者服用叠氮胸苷(AZT)100mg一天2次,TMPc02片1天2次。至1997年12月18日体重由72公斤增至88公斤,且恢复工作如前。