carcinogenesis
carcinogenesis
1. Interaction among Survivin, p53 and bcl-2 might participate in carcinogenesis of retinoblastoma.
(2)Survivin、P53和bel一2可能通过相互作用共同参与Rb的发生发展。
2. In 1997 the World Health Organization claimed dioxin to be a category one carcinogen.
1997年世界卫生组织已将其列为人类一级致癌物。
3. In 1997 the International Agency for Research into Cancer reclassified silica as a Group 1 carcinogen - “known to cause human cancer”.
1997年国际癌症研究机构将二氧化硅重新分类为1类致癌物-明确可以导致人类癌症。
4. The correlation of the two ADAs with AFB 1 induced carcinogenesis was also discussed.
ADA的两种主要加合物的生成、分布和清除以及它们与AFB1致癌作用的关系也作了讨论。
5. LOH at APC/MCC locus plays an important role at the early stage of carcinogenesis and progress, while LOH at DCC locus occurs at a later stage and may be correlated with prognosis of patiets.
APC/MCC基因LOH在胃癌的早期发生及发展中起作用，而DCC基因LOH则是晚期改变，可能与临床预后相关。
6. These data suggest that LOH at APC, MCC and DCC loci in esophageal carcinoma is, to certain extent, a common genetic alteration which might play a role in esophageal carcinogenesis.
APC、MCC和DCC基因位点的杂合性丢失在一定程度上是食管癌基因改变的普遍现象，并可能在肿瘤的发生中起作用。
7. Bcl-2, Bax,Bcl-xl proteins might participate in the carcinogenesis and development of BCC.
Bcl-2、 Bcl-xl、 Bax蛋白可能参与了基底细胞癌的发生、发展。
8. CD44v6 was significantly associated with the carcinogenesis and development of ESC,suggesting it may be looked as a new tumor marker.
CD4 4v6与ESC的发生发展有关 ,可作为ESC的一种新的肿瘤标记物
9. Abnormal expression of COX-2 may be the early events in colon carcinogenesis and play pivotal roles in the progression of colon cancer.
COX-2异常表达可能是结肠癌发生的早期事件,且在结肠癌的发生、发展中起一定作用。
10. The over expression of cyclinD1 may participate in the carcinogenesis and progression of HCC.
CyclinD1基因的过度表达可能参与HCC的发生、发展。
11. In the fields of epigenetics and epigenomics, DNA methylation has been drawn a special attention because of its close correlation to human development and carcinogenesis.
DNA甲基化已经成为表观遗传学和表观基因组学的重要研究内容，人类表观基因组计划的最终目标是绘制出人类基因组中甲基化可变位点图谱。
12. Loss of VHK gene may be a late event of carcinogenesis of TCC.
FHIT基因和hMLH1基因的缺失作为分子标志有可能为膀胱TCC的早期诊断提供新的途径和依据 ,而VHL基
13. Allelic loss at the FRA3B site occurs frequently in NPC. This suggests that the region between D3S4103 and D3S4260 may represent a preferential molecular target in nasopharyngeal carcinogenesis.
FRA3B脆性部位的LOH为鼻咽癌的频发事件,可能参与了鼻咽癌的发生发展,共同缺失区D3S4103-D3S4260可能是其优先作用的分子靶点。
14. The infection of HPV-16/18 may be related to the carcinogenesis of TCC of the urinary bladder.
HPV 16/18感染可能与膀胱TCC发生相关 ;
15. GOI of IGF2 may take part in human hepatocellular carcinogenesis.
IGF2基因印迹的重新获得可能参与了肝癌的发生
16. The findings indicate that LOH at MCC, DCC and YNZ22 loci may beinvolved in carcinogenesis of colorectal cancer, and LOH of DCC is frequently a late event intumor progression.
MCC、DCC基因和YNZ22位点的LOH与大肠癌发生、发展有关，DCC基因LOH多为大肠癌的晚期改变。
17. The low expression of P33~(ING1) may be an important factor related to carcinogenesis and development of OSCC.
P33ING1蛋白在口腔鳞状细胞癌组织中的表达下降,提示P33ING1蛋白可能在口腔鳞癌的发生发展中有重要意义。
18. Overexpressions of p 53 and C erbB 2,C ras,C myc have some effects on carcinogenesis,tumor progression and prognosis of patients with GCT.
p53及C－erbB2、C－ras、C－myc的表达对卵巢粒层细胞瘤的发生、发展及患者预后有一定的影响。
19. Thus the results suggest that ras activation, p53 mutation and the increase of cellular DNA content play a certain role in the carcinogenesis of colorectal adenomatous polys.
ras激活，p53突变及细胞DNA含量的增高，均在大肠腺瘤样息肉癌变中发挥了一定作用。
20. The expressions of SKP2 and p27 may act as important biological markers to reflect carcinogenesis, progression, biological beheviors and prognosis of gastric carcinoma.
SKP2和p27可能是反映胃癌发生、进展、生物学行为及预后的标记物。
21. "There are no studies showing any safe leel of exposure to this potent lung carcinogen," said lead author Michael J.
“目前尚无研究表明体内NNK这一潜在的肺癌致癌原达到什么水平才会引起危害。”
22. Human hazards of acrylamide: the animal experiments show that, acrylamide is a kind of potential carcinogen.
丙烯酰胺对人体的危害：动物试验显示，丙烯酰胺是一种可能致癌物。
23. It is well known that human esophageal carcinogenesis is a multifactorial, multistep process.
临床上所见的食管癌患者大部分已有晚期转移,这些患者的预后往往很差。
24. It is well known that human esophageal carcinogenesis is a multifac torial, multistep process.
临床上所见的食管癌患者大部分已有晚期转移，这些患者的预后往往很差。
25. In order to investigate the roles of expression of bcl-2 protein and LOH at DCC gene in the carcinogenesis of gastric cancer,the expression of bcl-2 protein and LOH at DCC gene were detected by immunohistochemical technique and PCR method.
为了研究bcl?2蛋白表达和DCC基因的杂合性缺失（LOH）在胃癌发生中的作用，采用免疫组织化学技术和PCR方法检测了胃癌组织bcl?2蛋白的表达和DCC基因的杂合性丢失（LOH）。
26. Dioxin is a carcinogen, officials are worried that these latest findings will lead to Ireland's beef exports hit again.
二恶英是一种致癌物质，官员担心，这些最新发现将导致爱尔兰的牛肉出口再受重创。
27. Secondhand smoke, known as a human carcinogen, contains more than 50 cancer-causing chemicals.
二手烟雾是已知的人类致癌原，包含超过50种致癌化学物质。
28. When the tautomer DTP(1,3,7) reacts with the electrophilic carcinogen BPDE,the atomic S10 of DTP(1,3,7) superiorly attacks the BPDE.
二硫酮DTP(1,3,7)在水相中与致癌物BPDE进行亲核取代反应时,二硫酮DTP(1,3,7)中的S10原子优先进攻亲电试剂BPDE.
29. Nitrites material is a carcinogen, such as excessive intake, not human metabolism, accumulation in the body, the body will cause harm.
亚硝酸盐类物质是一种致癌物质，如摄入过多，人体不能代谢，蓄积在体内，会对机体产生危害。
30. Sodium nitrite is easily converted to nitrite amine, which is a kind of carcinogen.
亚硝酸钠在人体内容易转变为亚硝胺，是一种致癌物质。
31. The investigation on the role of DNA methylation in carcinogenesis have been mainly focused on promoter hypermethylation of tumor suppressor genes.
关于DNA甲基化在肿瘤中的作用的研究，大多集中在研究已知的抑癌基因启动子区的异常高甲基化。
32. Keywords: Lung development, neurogenic genes, oxygen sensing, airway chemoreceptors, pediatric and adult lung disease, lung carcinogenesis.
关键词：肺发育，神经基因，氧敏感，气道化学感受器，儿童和成人肺疾患，肺癌形成
33. The other carcinogen of concern, with regulations beingset by the EPA, comes from the release of asbestos with asbestos removal activities.
其他致癌污染源，EPA法规规定，是来自石棉的石棉清拆活动中释放。
34. It could also induce human carcinogenesis and has hematotoxicity and neurotoxicity.
具有致癌作用以及血液、神经系统毒性。
35. It is currently considered by the IARS to be a possible human carcinogen(group 2B) on the basis of " sufficient" animal date and " inadequate " human date.
动物试验表明铅对动物有致癌性,对人类是可能的致癌物,国际癌症联合会将其列入2B类致癌物。
36. Chemical carcinogens generally require metabolic conversion to some form of "ultimate" carcinogen.
化学致癌物一般需要通过代谢来转换成某种形式的“最终”致癌物。
37. Pumpkin can remove the choppy effect of carcinogen, check cancer cell appears.
南瓜能消除致癌物质的突变作用，制止癌细胞出现。
38. Farinati F,Cardin R,Degan P,et al.Oxidative DNA damage accumulation in gastric carcinogenesis[J].Gut,1998,42(3):351.
厉有名,马先槎,许德兴,等.幽门螺杆菌与胃窦粘膜肠化生的关系[J].中华医学杂志,1996(11):863.
39. Last year, the World health Organization determined that nightshift work, which can lead to sleep troubles, is a probable human carcinogen.
去年，世界卫生组织确定，夜间工作会导致睡眠障碍，这可能是致癌的一个原因。
40. In addition, hypermethylation at a region next to such a critical region might indicate an early signal of carcinogenesis.
另外,紧靠这些临界区域的超甲基化可能暗示致癌作用的早期信号。
41. Gerri Willis: Well, it's because it stirs carcinogen.
哦，那是因为它会散发出致癌物质。
42. Because alcohol will be deliquescent in smoke tar, make carcinogen move arrive inside cellular film.
因为饭后人体热量大增，这时吸烟会使蛋白质和重碳酸盐的基础分泌受到抑制，妨碍食物消化，影响营养吸收。
43. Therefore, we hypothesize that demethylation of these genes occurs during the progressive stages of gastric carcinogenesis, after global DNA hypomethylation.
因此,我们假定:在总DNA低甲基化后,这些基因的去甲基化发生于致胃癌作用的进展期。
44. While the molecular pathways of gastric carcinogenesis are dependent on histological background, specific genetic alterations can still be used for risk assessment, diagnosis, and prognosis.
因此,胃癌变的分子途径依赖于组织学背景,特定基因的改变仍然可用于危险率评估,诊断和评价预后。
45. In 2007, the International Agency for Research on Cancer (IARC) reclassified working at night from a possible to a probable (group 2A) human carcinogen.
在2007年，国际肿瘤研究机构（IARC）将夜班工作重新分级，从可能导致人类致癌级别调整到很可能致癌级别（2A组）。
46. ID-1 and IGF-1R played important roles in the carcinogenesis of ESCC,ID-1 expression may be involved within the regulation of apoptosis but notproliferation of ESCC cells.
在ESCC中ID-1的表达上调,且与bcl-2的表达呈正相关而与Ki-67表达无关,提示ID-1参与抑制细胞凋亡的调控,而不参与调控细胞增殖;
47. Chemical carcinogenesis in culture has proved to be a much more difficult field of investigation than viral carcinogenesis.
在培养内化学致癌已证明是一个比致癌困难得多的研究领域。
48. Among river polluttions, carcinogen and substances which cause mutation and malformation are most poisonous and most harmful to human health.
在河流污染物中，致癌物、致突变物、致畸形物（简称“三致”物）毒性最强，对人体健康威胁最大。
49. Conclusion: Wounding and benzoyl peroxide can increase the carcinogenesis induced by DMBA in hamster tongue.
在进行流行病学调查、癌变发生和预防上应考虑物理和化学因素对癌形成的促进作用。
50. An extension of these ideas is embodied in the theory of ALLISON concerning carcinogenesis.
在阿利森的癌症发生学说中，这些概念得到发挥。
51. To summarise it, Dr Campbell states, "No chemical carcinogen is nearly so important in causing human cancer as animal protein".
坎贝尔博士总结说：“动物蛋白比任何一种化学致癌物都更容易引发癌症。”
52. Tumor angiogenesis correlated with carcinogenesis and development in colorectal carcinoma.
大肠癌血管形成与其发生、发展的关系。
53. When cancer is viewed as a chromosomal disease, carcinogens, rare genetic syndromes and accidental mitotic errors can initiate carcinogenesis by inducing random aneuploidies.
如果将癌症视为染色体疾病，那麽致癌物质、罕见遗传病症以及有丝分裂的意外出错，都会经由随机造成的非整倍体而促使癌症发生。
54. Tsujitane S,Shirai H,Tatebe,et al.Apoptotic cell death and its relationship to carcinogenesis in colorectal carcinoma[J].Cancer,1996,77(8):1711.
孙保存,赵秀兰,惠京,等.大肠癌及其癌前病变中细胞凋亡与细胞增殖关系的原位观察[J].中华医学杂志,1996,76(4):848.
55. Safe use: not produce any organic chloride and other harmful substances that may lead to carcinogenesis, teratogenesis and mutagenesis, such as THMS and chloroform.
安全：不会产生“三致物质”的有机氯化物和三氯甲烷、氯仿等物质；
56. Experimental studies have showed its effects in inhibiting metastases,apoptotic induction,cell signal transduction and prevention of liver carcinogenesis.
实验研究发现其具有抗转移、诱导肿瘤细胞凋亡、影响细胞信号转导以及预防肝癌发生的作用。
57. The research of autophagy has revealed the effect of autophagy on carcinogenesis and provides us a promising avenue for cancer therapy and prevention.
对于自噬作用的研究进一步揭示了肿瘤发生、发展的潜在机制，也为肿瘤的治疗和预防提供了新的思路。
58. Moreover,carcinogenesis induced or promoted by non-genotoxic chemicals and its mechanism of action were discussed.
对化学致癌物引起的表观遗传改变可以在代间相传这一新发现作了简要介绍;
59. Moreover, carcinogenesis induced or promoted by non-genotoxic chemicals and its mechanism of action were discussed.
对化学致癌物引起的表观遗传改变可以在代间相传这一新发现作了简要介绍；
60. The jeopardy,mechanism,analysis method and elimination method of ethyl carbamate(EC) was summarized to enhance the social recognition of it as a carcinogen.
对氨基甲酸乙酯的危害、形成机制、分析和消除方法进行了综述,应加强对氨基甲酸乙酯这种致癌物质的认识,引起社会的关注。
61. The changes of 8-OH-dG in the progress of carcinogenesis were detected in human bronchial epithelial cells induced by Benzo(a)pyrene diol-epoxide(BPDE)and sulfide nickel(NiS) in vitro.
并利用苯并 (a)芘代谢产物B(a)P 二醇 环氧化物 (BPDE)和结晶型硫化镍 (NiS)诱导的体外人支气管上皮细胞转化癌变模型 ,检测癌变进程中 8 OH dG的变化。
62. Microwaving prepared meats sufficiently to insure sanitary ingestion caused formation of d-Nitrosodienthanolamines, a well-known carcinogen.
微波肉充分准备，以确保卫生摄入形成造成的D - Nitrosodienthanolamines ，一个众所周知的致癌物质。
63. Conclusion Our findings suggest that the promoter hypermethylation of RASSF1A and p16 could play an important role in esophageal squamous cell carcinogenesis.
总结 本研究发现RASSF1A和p16启动子的甲基化可能是食管癌发生机制中早期的分子生物学变化，在食管癌的发生过程中起到了重要的作用。
64. The term of chronic irritation as a carcinogen is so vague that it is not easy to discuss.
慢性刺激作为致癌因子，其意义是如此含糊以致不易加以讨论。
65. We suggest that whey protein may be exerting its effect on carcinogenesis by enhancing GSH concentration.
我们认为：乳浆蛋白通过升高谷胱甘肽水平而产生抗肿瘤的效果。
66. Therefore, the World Health Organization benzene compounds have been identified as a strong carcinogen.
所以苯化合物已经被世界卫生组织确定为强烈致癌物质。
67. The expression of genes can be “silenced” by hypermethylation of the tumor suppressor genes, which induces carcinogenesis.
抑癌基因启动子高甲基化可以使其表达失活,导致肿瘤发生。
68. According to the USW, the US Environmental Protection Agency's Science Advisory Board describes PFOA as a 'likely carcinogen'.
据联合钢铁工人协会，美国环境保护局的科学咨询委员会介绍了全氟辛酸铵作为一种'可能致癌' 。
69. The results indicate that P21-H-ras,EGFR and P53 are involved in the carcinogenesis of FAP,P21 H-ras and EGFR may be in the early stage,and P53 may be in the late stage.
提示P21－H－ras、EGFR、P53基因都参与FAP癌变，P21－H－ras基因、EGFR可能作用于早期，P53基因则作用于晚期。
70. The results indicated that nm23 H 1 might play an important role in the carcinogenesis and development of human esophageal squamous cell carcinoma.
提示：nm23?H1在人食管鳞癌发生发展过程中起重要的抑制作用。
71. These findings indicated that genetic polymorphisms in metabolic enzymes and environmental risk factors might play an important role in the carcinogenesis of gastric cancer.
携带肿瘤易感基因的胃癌高风险人群更应加强防范环境致癌物的暴露，以降低胃癌发病率和死亡率。
72. Abstract Objective: To study the relation between nucleolar oryanizer regions（NOR） and the trend of carcinomatous changes during oral carcinogenesis.
摘 要 目的：比较口腔粘膜癌变过程中核仁组织区（NOR）的变化及与癌变趋势的关系。
73. Abstract: Pyrrolizidine alkaloids(PAs) are widely distributed in plantae.Many PAs are hepatotoxic,Lung toxicity(carcinogenesis),neurotoxic and cytotoxic.
摘 要： 吡咯里西啶生物碱广泛分布于植物界。
74. DNA adducts is a very important class of biomarkers of human exposure to carcinogen, cancer risk assessment, and population susceptibility.
摘要 DNA加合物是一类重要的生物标志物,可应用于人体致癌物暴露监测、癌症风险评价和人群易感性研究。
75. Acrylamide is a neurotoxin and a probable human carcinogen.
摘要丙烯酰胺是一种神经毒素及对人可能的致癌物质。
76. Modifications of DNA by endogenous or environmental reactive species could lead to mutation during DNA replication, which is the initiation step of carcinogenesis.
摘要去氧核醣核酸(DNA)被体内或环境中具反应性物种修饰后会在DNA复制时导致基因突变，为细胞癌化的第一步。
77. The jeopardy mechanism, analysis method and elimination method of ethyl carbamate (EC) was summarized to enhance the social recognition of it as a carcinogen.
摘要对氨基甲酸乙酯的危害、形成机制、分析和消除方法进行了综述，应加强对氨基甲酸乙酯这种致癌物质的认识，引起社会的关注。
78. This paper summarizes recent developments in colorectal cancer carcinogenesis, early diagnosis, comprehensive treatment and chemoprevention.
摘要本文总结了近年来在结直肠癌癌变机理、早期诊断、综合治疗、化学预防方面的研究新动向。
79. Pitch Fume is a kind of carcinogen, which can cause severe harm to the health of human beings.
摘要沥青烟是一种较强的致癌物质，对人的健康会造成极大的伤害。
80. Bromate is a kind of disinfection by-products of drinking water.Since it has been proved to be a potential human carcinogen it has received considerable attention from analysts.
摘要溴酸盐是用臭氧对饮用水进行消毒时产生的一种副产物，是一种潜在的致癌物。
