histone
histone
1. Su(ar)3-9 proteins attach methyl groups to the histone labeled H3 at its ninth amino acid residue, which is a lysine.
9蛋白将甲基加在组蛋白H3的第九位氨基酸残基，也就是赖氨酸残基上，从而使H3组蛋白贴上了个标签。
2. Depletion of maternal BRG1 did not affect global levels of histone acetylation, whereas dimethyl-H3K4 levels were reduced.
BRG1蛋白的缺失没有影响组蛋白乙酰化的整体水平，但是二甲基H3K4的水平有所降低。
3. Role of histone acetylation in the differentiation of human gastric cancer cell induced by DADS in vivo
DADS体内诱导人胃癌细胞分化作用中组蛋白乙酰化的变化
4. Brownian dynamics simulation of the interaction between DNA and histone
DNA与组蛋白相互作用的布朗动力学研究
5. DNA has negative charges and histone has positive ones.So the interaction between them is coulombic force.
DNA分子带强负电而组蛋白则带正电，库仑相互作用起主要的作用。
6. DNA Methylation, Histone Modifications and Genes Silencing
DNA甲基化、组蛋白修饰与基因沉默
7. DNA methylation has an important role in transcriptional regulation, togethering with histone modification and chromatin remodeling.
DNA甲基化在基因转录过程中扮有重要角色，并与组蛋白修饰、染色质构型重塑共同参与转录调控。
8. DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators.
DNA甲基化由DNA甲基转移酶催化 ，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。
9. DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription,induce gene silencing at the participation of many regulators.
DNA甲基化由DNA甲基转移酶催化,在多种调节因子的参与下,与组蛋白修饰相互作用,抑制基因转录,导致基因沉默。
10. Keywords DNA methyltransferases;Histone methyltransferase;Methylation;Epigenetics;Colon cancer;Reverse transcription-polymerase chain reaction;
DNA甲基化酶;组蛋白甲基化酶;甲基化;表观遗传学;结肠癌;逆转录聚合酶链式反应;
11. DNA hypomethylation,likely to be cooperating with aberrant histone modification,may induce the activation of some T cell genes and development of autoimmunity in SLE.
DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化,导致狼疮自身免疫的发生。
12. FK228 with a special depsipeptide may efficiently pass through the cellular membrane and exert a prominent anti-tumor activity by inhibiting histone deacetylase.
FK228具有特殊的缩酯环肽结构,可有效透过细胞膜,通过抑制组蛋白去乙酰酶而显示良好的抗肿瘤活性。
13. HIR/HIRA,encoded by Hir/Hira(histone regulation) genes,were identified as negative regulators of histone gene expression.
H ir/H ira基因产物是组蛋白基因表达的一种负调节因子,其在果蝇发育过程中的作用还没有得到确认.
14. H2A histone
H2A组蛋白(组织学)
15. H3 histone
H3组蛋白
16. H4 histone
H4组蛋白
17. The histone deacetylases inhibitors (HDACIs) are potent inducers of growth arrest, differentiation and apoptosis of tumor cells, and have entered clinical trials for both solid and liquid tumors.
HDAC抑制剂能够引起肿瘤细胞生长停滞、诱导肿瘤细胞分化和凋亡。
18. HIR/HIRA,one of the histone chaperones,encoded by Hir/Hira(histone regulation) genes,were initially identified in yeast as negative regulators of histone gene expression.
Hir/Hira基因产物HIR/HIRA为组蛋白的伴侣蛋白,最先作为组蛋白基因表达的一种负调节因子从酵母中被鉴定出来。
19. MYST histone acetyltransferase
MYST组蛋白乙酰转移酶
20. Ser-10 phosphorylated histone
Ser10磷化的组蛋白H3
21. SET domain proteins of SUV3-9H family specifically methylate the residue lysine 9 of histone H3, resulting in gene silencing.
Su(var)3-9家族的SDP专一甲基化组蛋白3第9位赖氨酸(H3K9),从而导致基因沉默(gene silencing)。
22. Z associates with functional regulatory elements, and CTCF marks boundaries of histone methylation domains.
Z和功能调控元件相关，CTCF标记组蛋白甲基化区域边界。
23. A Novel Member SET07 from Histone Methyltransferases(HMT) Family
一个新的HMT家族成员SET07的理化性质及其功能
24. Sensitive assay system for inhibitor screening and kinetic assays of HDAC1 (histone deacetylase 1).
一种用于抑制剂筛选和HDAC1动力学检测的敏感检测系统。
25. " Recent high throughput technologies, such as "ChIP-chip" and "ChIP-seq," have generated high resolution maps for many histone modifications on the human genome.
中科院韩敬东研究组在此基础上，利用贝叶斯网络推测组蛋白各种不同修饰和基因表达之间的因果关系及组合关系。
26. As a test to determine whether such histone modification functionally affected plasticity, the researchers administered a drug to adult mice that would increase chemical modification of histone.
为了确定组蛋白的化学修饰是否对大脑可塑性产生功能上的影响，研究人员做了一个试验，即给予成年鼠服用一种能够增加组蛋白化学修饰的药物。
27. Keywords Acetylation,Drosophila,hsp gene,polytene chromosome, histone deacetylase inhibitor;
乙酰化;果蝇;热休克基因;多线染色体;去乙酰化酶抑制剂;
28. Regulation of histone acetylation on the expression of cell cycle-associated genes in human colon cancer cell lines
人结肠癌细胞中组蛋白乙酰化对细胞周期调节基因表达的影响
29. We will further investigate the relationship of histone modification and promoter methylation on the expression of TFPI-2.
今后，我们将在表观遗传层面对TFPI-2基因的修饰和相关组蛋白的修饰进行深入研究。
30. They also concluded that the closure of the critical period was associated with a decrease in the ability of isual experience to drie the histone modifications that are necessary for neural rewiring.
他们同时说道，神经系统的重新架构有赖于组蛋白的化学修饰，而视觉体验刺激产生化学修饰的能力下降与临界期的终止具有相关性。
31. For example, histone acetyltransferase (HAT) complexes are thought to activate gene expression by modifying chromatin-associated proteins called histones which function like spools for DNA to wind around.
例如,组蛋白乙酰转移酶(HAT)复合物被认为是通过修饰与染色质相连的被称作组蛋白的蛋白质来激活基因表达的过程,而组蛋白的功能是被当作让DNA缠绕的线轴。
32. Keywords gene expression;histone;cell cycle;
关键词基因表达;组蛋白;细胞周期;
33. Keywords Lung adenoma;A549cells;Histone de acetylase 1（HDAC1）;Hypoxia;
关键词肺腺癌;A549细胞株;组蛋白去乙酰化酶1;低氧;
34. Title： Cloning, expression and transcriptional activity of Bm-mof, an MYST histone acetyltransferase gene in the silkworm, Bombyx mori L.
关键词：家蚕;MYST组蛋白乙酰转移酶;克隆;序列分析;表达谱
35. One example of such modifications is histone ubiquitination, which occurs predominately on histone H2A and H2B.
其中一种修饰作用就是发生于组蛋白H2A和H2B的泛素化作用。
36. One way they do this is by acetylation of the H3 histone's fourth amino acid, also a lysine.The effect is to open the chromatin at that site, making the DNA accessible.
其作用方式之一是使H3组蛋白的第4个氨基酸（也是赖氨酸）残基乙酰化，使染色质在这一部位展开，而DNA变得易于接近。
37. Histone acetylase
去乙酰化酶
38. Keywords deacetyase;gene expression;histone;cell cycle;
去乙酰化酶;基因表达;组蛋白;细胞周期;
39. The Regulatory Mechanisms of Reversible Histone Acetylation on Human IL-5 Gene Transcription
可逆的组蛋白乙酰化修饰对人白细胞介素5基因转录的调控作用及机制研究
40. There are two kinds of molecular containing histone deacetylase activity: One is homology with yeast RPD3,and another is not homology with yeast RPD3.
含有组蛋白脱乙酰化酶活性的分子有两类:一类是与酵母RPD3同源的分子,另一类是与RPD3不同源的分子。
41. Cyclic tetrapeptide histone deacetylases inhibitors containing L-phenylalanine: cyclo(-Ab7-Aib-Phe-D-Pro-);
含有苯丙氨酸的环四肽结构cyclo(-Ab7-Aib-Phe-D-Pro-)
42. Cyclic tetrapeptide histone deacetylases inhibitors containing L-methylphenylalanine:cyclo(-Ab7-Aib-Phe(X-Me)-D-Pro-);
含甲基苯丙氨酸坏四肽结构cyclo(-Ab7-Aib-Phe(X-Me)-D-Pro-)
43. THE PRELIMINARY STUDY OF ULTRA-HISTOCHEMISTRY OF HISTONE OF THE OVULE OF BEGONIA SEMPERFLORENS AND THE RADICLE OF GINKGO BILOBA
四季海棠胚珠及银杏胚根的组蛋白超微组织化学的初步研究
44. In prokaryotes the nuclear material is simply a circular strand of DNA, not complexed with histone proteins, and cell division is amitotic.
在原核生物中，核物质仅是一个简单的环状DNA，而不与组蛋白结合，并且细胞为无丝分裂。
45. SATB1 also globally regulates histone status in the chromatin by recruiting histone-modifying enzymes to the target-gene loci.
在染色体中，SATB1还在靶基因位置上通过复活组蛋白修饰酶普遍的调节组蛋白的状态。
46. In eukaryotic cells, DNA is located in nucleolus in the form of chromatin by combining with histone proteins.
在真核生物中，DNA分子缠绕在组蛋白上形成染色质保存在细胞的细胞核中。
47. During histone exchange, chromatin remodeling complex facilitates histone variant deposition into nucleosome, and different variants have diverse deposition pathways.
在组蛋白替换过程中，组蛋白变体是通过相应的染色质重构复合物组装人核小体，不同的变体有着不同的组装途径。
48. The role of histones in this drama is not clear, but recent work has shown that the protein tails that hang off the histone spools can sport an impressive array of chemical additions.
在这场戏剧演出当中，组织蛋白扮演的角色并不清楚；不过近来的研究显示，位于组织蛋白线轴尾端的蛋白质上头，可以见到让人印象深刻的一串化学修饰。
49. We numerically simulate the interaction between DNA and a histone.And we get the nucleosome structure.DNA wraps around histone about 2 loops.
在适当的参数条件下，得到了合理的结果，即DNA能够缠绕组蛋白约两圈形成准核小体结构。
50. Immunogenicity of the recombinant archaeal histone as a non-viral gene delivery
基因药物载体重组古菌组蛋白的免疫原性研究
51. Recent studies showed that some transcriptional regulators with histone acetyltransferase(HAT) and deacetylase(HDAC) activities may play a causative role in regulating gene expression.
多种具有组蛋白乙酰化酶(HAT)和组蛋白去乙酰化酶(HDAC)活性的调节因子，通过对组蛋白乙酰化过程的调节，在基因表达调控中发挥着重要作用。
52. Keywords malignant tumors of head and neck;histone acetylation;histone deacetylation;histone deacetylase inhibitor;
头颈部恶性肿瘤;组蛋白乙酰化;组蛋白去乙酰化;组蛋白去乙酰化酶抑制剂;
53. The Effect of Curcumin on Expression of P300,P53,c-myc and Acetyl Histone H3,H4 in the Gastric Cancer Cell
姜黄素对胃癌细胞P300、P53、c-myc及乙酰化组蛋白H3和H4表达的影响
54. Effects of curcumin on the acetylation of histone H3, P53 and the proliferation of NB4 cells
姜黄素调节NB4细胞P53和组蛋白H3乙酰化抑制细胞增殖的研究
55. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants tails.
对于不同状态的染色质，核小体中会组装人相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
56. To adapt to various states of chromatin, corresponding histone variants are incorporated in nucleosome, and certain modifications also occur on the variants’ tails.
对于不同状态的染色质，核小体中会组装入相应的组蛋白变体，并且各种组蛋白变体的尾部也能发生多种修饰。
57. Study of Histone H3.3 and Transcription Factor dE2F1 in Drosophila
对果蝇中组蛋白H3.3和转录因子dE2F1的研究
58. Recently, research on histone variants is not only a new hotspot in epigenetics, but also a new annotation of "histone code".
对组蛋白变体的研究是近年来表观遗传学新的研究热点，也是对“组蛋白密码”的新的诠释。
59. Keywords Triticum aestivum;histone modification enzyme gene;DNA methyltransferase gene;gene cloning;gene expression;
小麦;组蛋白修饰酶基因;DNA甲基转移酶基因;基因克隆;基因表达;
60. Isolation and Characterization of Genes Encoding Histone Modification Enzyme and DNA Methyltransferase in Wheat (Triticum Aestivum.L)
小麦组蛋白修饰酶基因及DNA甲基转移酶基因的分离及鉴定
61. Despite the ubiquitous nature of histones, T cell recognition of histone H4 peptide was specifically associated with the presence of prostate cancer in these mice.
尽管组蛋白无处不在，对于组蛋白H4肽的识别与这些鼠中的前列腺癌的存在特异性相关。
62. In addition, histone exchange reveals new changing mechanism of DNA-histone interaction.
并且，组蛋白替换揭示了DNA-组蛋白相互作用变化的一种新的机制。
63. Study of interactions between DNA and histone with molecular combing method
应用分子梳技术对DNA与组蛋白相互作用的研究
64. Keywords ] Cardiac hypertrophy;Histone deacetylase 2;Valproate sodium;Genetic transcription;
心肌肥大;组蛋白脱乙酰基酶2;丙戊酸钠;基因转录;
65. Robert Fleck's world now revolves around the Ridgeons Premier Division, where the team he manages will face up to the might of Soham Town Rangers, Harwich &Parkeston, and Histon Reserves.
我们在迪斯城的俱乐部会所里聊天，接着他们要面对本赛季与剑桥城队的公开赛。
66. As a result, we found that the C-terminal fragment of HBO1 (histone acetyltransferase binding to ORC1), an MYST family histone acetyltransferase, interacted with CDK11p58 in yeast.
我们进一步研究发现在体外HAT检测反应体系中直接加入原核表达的CDK11p58纯化蛋白，能显著促进HBO1对的HAT活性；
67. Keywords antinuclear antibody（ANA）;immunogenicity;histone;autoimmunity;
抗核抗体;免疫原性;组蛋白;自身免疫;
68. This article reviews a number of startling observations about the extent of non-protein-coding RNA transcriptions、DNA methylation and covalent histone modifications in the complex organisms.
拟从非编码RNA、DNA甲基化和组蛋白共价修饰3个层面介绍这方面的研究进展。
69. HIR/HIRA, one of the histone chaperones, encoded by Hir/Hira (histone regulation) genes, were initially identified in yeast as negative regulators of histone gene expression.
摘要Hir/Hira基因产物HIR/HIRA为组蛋白的伴侣蛋白，最先作为组蛋白基因表达的一种负调节因子从酵母中被鉴定出来。
70. The hypothesis of "Histone code" suggests an existing way of program information of eukaryotic gene control.
摘要“组蛋白编码”假说提示了真核生物基因调控的程序性信息的存在方式。
71. Starting with 2 main mechanisms (DNA methylation and histone acetylation) of the apparent reprogramming, the abnormalities of the apparent reprogramming in the somatic cloning animals were summarized.
摘要从表观重编程的两大主要机制（DNA甲基化和组蛋白乙酰化）入手，对体细胞克隆动物的表观重编程异常展开了综述。
72. Histone lysine methylation plays a key role in epigenetic regulation.
摘要组蛋白赖氨酸的甲基化在表观遗传调控中起着关键作用。
73. Epigenetics refers to the heritable changes in gene expression without any alteration in DNA sequence, including DNA methylation, histone modification and chromatin conformation.
摘要表观遗传学是指基于非基因序列改变所致基因表达水平的变化，如DNA甲基化和组蛋白修饰等；
74. We numerically study the interaction between DNA and histone using a Brownian dynamics simulation. The process of nucleosome formation is shown in detail.
文章作者运用布朗动力学,数值模拟了DNA与组蛋白相互作用最终形成核小体的动力学过程,揭示了DNA与组蛋白相互作用的详细图景,并提出了组蛋白八聚体旋转模型,以解释这一过程.
75. Epigenetics can regulate the transcription of MDR1 gene through the DNA methylation and histone modification,which lead to the high expression of P-gp,causing drug resistance.
最近研究证实，表遗传修饰在调控MDR1基因表达中起重要作用。
76. Effective inhibitor of protein kinase C (PKC)-catalyzed histone phosphorylation.
有效的PKC催化组蛋白磷酸化抑制剂。
77. Our lab will explore the molecular mechanism and biological functions of histone H2B mono-ubiquitination and its downstream histone H3 methylation events.
本实验室将对H2B单泛素化及其下游H3赖氨酸甲基化的分子机制和生物学意义进行研究。
78. This study was to investigate the effects of curcumin on the acetylation of histone H3 and the expression of p21WAF1/CIP1 gene in human lymphoma cell line Raji.
本研究探讨姜黄素对Raji细胞组蛋白H3的乙酰化作用和细胞周期素依赖性激酶抑制剂p21WAF1/CIP1基因表达的影响。
79. Chromosome banding patterns are correlated with unique patterns of histone modifications.
染色体带型和组蛋白修饰的特有模式相关。
80. Covalent modifications of histone tails play a key role in the regulation of chromatin structure and control of transcriptional activity.
染色体组蛋白的共价修饰在调节染色体结构,控制基因的转录等方面发挥重要的作用。
