lysosomal

lysosomal

1. MPS inhibits various aggressive lysosomal enzymes that degrade important constituents of connective tissue, such as elastase (degradation of elastin), collagenase (degradation of collagen) and hyaluronidase (degradation of hyaluronic acid).

MPS抑制了各种参与分解代谢的酶，这些酶用于降解结缔组织的重要组成元素，如弹性蛋白酶（降解弹性蛋白），胶原酶（降解胶原）和透明质酸酶（降解透明质酸）。

2. Once engaged by soluble or matrix-anchored ligands, cell surface proteins are commonly sorted to lysosomal degradation through several endocytic pathways.

一旦溶解配基或者基质固定配基参与，细胞表面蛋白一般通过几个细胞内吞途径被溶酶体降解。

3. Furthermore, we successfully induced metastatic behaviors of RasV12 cells by blocking the lysosomal degradation pathway with anti-malarial drug chloroquine or monensin.

为了进一步探讨内吞运输途径和肿瘤转移的关系，我们分别利用抗虐疾药物氯喹和莫能菌素阻断溶酶体的降解功能，成功地在RasV12肿瘤细胞中模拟了肿瘤转移的表型。

4. inborn lysosomal diseases

先天性溶酶体病

5. Keywords Prenatal diagnosis;Molecular diagnostic techniques;Neuronal ceroid-lipofuscinosis;Allele specific primer extension （ASPE）;Lysosomal lipoprotein storage disease;

关键词产前诊断;分子诊断技术;神经元蜡样质脂褐质沉积病;等位基因特异性引物延伸法;溶酶体脂蛋白沉积病;

6. atherosclerosis was chosen as a first target because the evidence that lysosomal aggregates cause it is more universally accepted than for other targets.

动脉硬化症被选择为第一个靶标，因为溶酶体聚集物引起动脉硬化症的证据，比其他的靶标更普遍地被接受。

7. Atherosclerosis ;Proteins ;overexpress ;Acid lipase ;lysosomal ;

动脉粥样硬化 ;

8. It has been proposed that these fragments represent lysosomal products regurgitated to the tubular lumen4.

因此有人提出这些碎片是返流入肾小管管腔的溶酶体产物。

9. these enzymes are congenitally absent in sufferers of lysosomal storage diseases.

在溶酶体储存病患者中，天生缺乏这些酶。

10. Detailed analysis of complex lipids emphasizes the dissimilarity between the composition of lysosomal and plasma membranes.

复合磷脂的详细分析明显地表明了溶酶体膜与质膜的不同。

11. multiple lysosomal enzyme deficiency

多重溶酶体酶缺陷

12. The alimentary canal of most animals relies very little on lysosomal enzymes in digesting food.

大多数动物的消化道在消化食物时，很少有赖于溶酶体的酶。

13. It inhibits lysosomal enzymes in the catabolic phase of inflammation.

它能抑制参与炎症分解代谢的酶。

14. Ulinastatin was used to stabilize lysosomal membrane.

应用乌司他丁稳定溶酶体膜；

15. Some extracellular proenzymes may be activated by secreted lysosomal proteinases

有些细胞外酶原能被分泌的溶酶体蛋白酶所激活。

16. There are several mechanisms for lysosomal targeting, and the choice may vary depending on the enzyme;

有几种机制来进行溶酶体靶标，选择可能非常取决于酶；

17. According to its role of waste from different sources, is divided into autophagic lysosome and differences of lysosomal macrophages.

根据其作用废物的来源不同，分为自噬性溶酶体和异噬性溶酶体。

18. Lysosomal enzymes are not normally found in the cytosol.

正常情况下细胞溶质中不存在溶酶体的酶。

19. lysosomal hair loosing

溶菌酶脱毛

20. lysosomal acid phosphatase

溶酶体(的)酸性磷酸酶

21. Keywords Lysosomes;Mucolipidoses;Lysosomal storage diseases;nervous system;Deaf;Mice;

溶酶体;黏脂质累积病;溶酶体累积病;神经系统;聋;小鼠;

22. lysosomal DNA-ase

溶酶体DNA-酶

23. lysosomal alpha-N-acetylglucosamini-dase

溶酶体α-N-乙酰葡糖胺酶

24. lysosomal alpha-glucosidase

溶酶体α-葡糖苷酶

25. Lysosomal cystine augments apoptosis and causes the phenotype in cystinosis

溶酶体内胱氨酸可促进细胞凋亡并导致胱氨酸贮积症的表型发生

26. lysosomal compartment

溶酶体分割

27. Lysosomal elastase

溶酶体弹性蛋白酶

28. lysosomal trapping

溶酶体捕获

29. lysosomal residual body

溶酶体残余小体

30. lysosomal hydrolase

溶酶体水解酶

31. lysosomal disease

溶酶体病

32. THE PATHWAYS FOR THE LYSOSOMAL CELL DEATH

溶酶体的细胞死亡通路

33. lysosomal rupture

溶酶体破裂

34. lysosomal phosphatase

溶酶体磷酸酶

35. Morphological and functional alterations of ear in lysosomal neuraminidase gene deficient mouse

溶酶体神经氨酸酶基因缺乏小鼠听觉和耳形态学改变初步研究

36. lysosomal glycocerebrosidase

溶酶体糖基脑苷酯酶

37. lysosomal diseases

溶酶体缺陷症

38. lysosomal carboxypeptidase

溶酶体羧肽酶

39. Lysosomal carboxypeptidase B

溶酶体羧肽酶B

40. Lysosomal carboxypeptidase C

溶酶体羧肽酶C

41. lysosomal membrane

溶酶体膜

42. lysosomal membrane protein53

溶酶体膜蛋白

43. lysosomal storage disease

溶酶体贮存病

44. Lysosomal storage diseases

溶酶体贮积病

45. Keywords Lysosomal storage diseases;Diagnosis;Therapy;

溶酶体贮积病;诊断;治疗;

46. lysosomal pathway

溶酶体途径

47. lysosomal enzym

溶酶体酶

48. lysosomal enzymopathy

溶酶体酶病

49. Disorder of lysosomal enzyme

溶酶体酶病症

50. lysosomal enzymes

溶酶体酶类

51. lysosomal enzyme release

溶酶体酶释放

52. lysosomal acid phosphatase deficiency

溶酶体酸性磷酸酶缺乏症

53. lysosomal acid lipase deficiency

溶酶体酸脂(肪)酶缺乏

54. lysosomal acid lipase A

溶酶体酸酯酶A

55. lysosomal acid lipase B

溶酶体酸酯酶B

56. Lysosomal targeting experts and those involved in introducing genes into cells and mice and testing toxicity and efficacy would be involved at a later stage, typically in year 3 onward.

溶酶体靶标专家和那些把基因引入细胞与小鼠、测试毒性与效果的专家，将在后期介入（典型情况下在后3年）。

57. Expertise in lysosomal targeting would typically be proposed to enter the project in year 3.

溶酶体靶标的专门技术将作为典型被建议进入第3年的项目中。

58. lysosomal structrure

溶酶小体

59. While Sandhoff and Tay-Sachs are relatiely rare, one person in 5,000 is affected by a disease that falls into a category of lysosomal storage diseases.

然而山德霍夫氏病和泰伊-萨克斯病还是相对较少的，5000人中只有1人受到这种溶酶体贮积症的影响。

60. Objective: To explore the causes of the increase of lysosomal enzymes activity in the retina of hypertensive rats and the role of lysosomal enzymes in the damaged retina.

目的：探讨高血压大鼠视网膜溶体酶活性增强的原因及其在高血压大鼠视网膜病变中的作用。

61. Cathepsin B(CB) is a well-known lysosomal cysteine protease which has been studied in association with cancer invasion and metastasis.

组织蛋白酶B(CB)是存在于人体正常组织的一种半胱氨酸蛋白酶,与肿瘤的侵袭和转移密切相关。

62. Cathepsin is a class of intracellular lysosomal proteases and has a close relationship with the fibrosis and tumor development in multiple organs.

组织蛋白酶是溶酶体内的蛋白水解酶，与多种器官的纤维化和肿瘤有密切关系。

63. The main effect of yuanhuacine on the decidual cells was to alter the permeability of the lysosomal membrane.

芫花萜对蜕膜细胞的作用,主要是引起溶酶体膜通透性的改变。

64. Platelet lysosomal granulemembrane glycoprotein

血小板溶酶体膜糖蛋白

65. Phagocytosed tracer particles can permeate the whole lysosomal system.

被吞噬的标记颗粒能通过整个溶酶体系统

66. Kasperek G J. et al. Effect of exercise on liver protein loss and lysosomal enzyme levels in fed and fasted rats. Pro. Soc. Exp. Bio. Med. ,1980; 164:430-434

赵肖宪,等.运动干预对饮食性高胆固醇血症大鼠肝脂肪变影响.中国运动医学杂志199716(3)186-188

67. Sonication not only breaks lysosomal membranes but also releases some materials from the membrane.

超声处理不仅打碎了溶酶体的膜，还从膜上释放出某些物质。

68. The concept is a logical extension of the replacement of a natural lysosomal enzyme in people who are congenitally deficient for it, something that is already being done.

这个理念是病人天生缺陷的天然溶酶体酶置换的逻辑延伸，在这方面已经做了一些事情。

69. All together, these findings indicate that the Class C VPS complex mediated lysosomal degradation pathway plays an important role in metastasis.

这些结果表明，C类膜泡蛋白分选复合体介导的溶酶体降解途径可能在肿瘤转移过程中扮演重要角色。

70. As these lysosomal enzymes cause progressive damage of the connective tissue, the inhibiting effect of MPS leads to an improvement of tissue regeneration (Baici/Fehr).

这些降解酶会造成结缔组织的进一步损害，因而MPS对其的抑制作用有利于促进组织再生(Baici/Fehr)。

71. Such deficiencies cause lysosomal storage disorders, such as Gaucher's disease, and replacement of the gene is an effective treatment.

这样的缺陷引起溶酶体堆积病（例如，高歇病），基因置换是一种有效的疗法。

72. The enzyme plays a role in the lysosomal degradation of the N-glycosylprotein glycans.

这种酶在N-糖基化蛋白聚糖的溶酶体降解中起到作用。

73. Released kidney lysosomal enzymes may be concerned in the generation of erythropoietin.

释放的肾脏溶酶体的酶可能与产生促红细胞生成素有关。

74. 1.Higher ACP activity of target cells indicates the activation of lysosomal enzyme which serves as material basis for autolysis of the cells.

靶细胞内ACP酶含量增加,是靶细胞内溶酶体活化的表现,也是靶细胞自溶的物质基础。

75. Studies on Ultrastructure and Lysosomal Enzyme Cytochemistry of Entamoeba gingivalis

齿龈内阿米巴的超微结构与溶酶体酶细胞化学研究