mutagenesis
mutagenesis
1. "The cumulatie mutagenesis data suggest that infants exposed transplacentally to AZT may be at increased risk for cancer as they age," researchers said in a statement.
"积累的遗传突变数据指出婴儿经胎盘被传递给了AZT,随着他们年龄的增长可能会提高患癌症的风险",研究者在陈述中指出.
2. According to the different transcripts between the dominant genotype (CHN-2H) and nondominant genotype (CHN-2A), four infectious molecular clones of the nondominant genotype (CHN-2A) were constructed by site-directed mutagenesis technique.
CHN-2A还具有CHN-2H所不具备的另外两个RNA(命名为Reps和AD)。
3. OLIGOMAP - OLIGOMAP is a tool to help researchers engineer restriction sites into oligonucleotides using silent mutagenesis and reverse translation algorithms.
OLIGOMAP是一个帮助研究人员使用哑诱变和反向转换算法来约束寡核苷酸位置点的工具。
4. As a result, PB-mediated insertional mutagenesis permits for the first time the efficient production of mouse mutants for systematical functional analysis of the mouse genome.
PB转座系统第一次提供了在哺乳动物基因组水平高效诱变基因的工具，有助于系统地研究基因功能。
5. The promoter functional elements (-35 , -10 box andarchaeal DPE) were related. Site-directed mutagenesis of RM07 was performed in Escherichia coll.
RM07片段中的-35区、-10区特征序列和嗜盐古生菌启动子特征序列DPE在启动子功能上具有一定的相关性。
6. T-DNA insertional mutagenesis in fuctional genomics of rice.
Symposium on 10th SCBA (Society of Chinese Bioscientists in America) International Symposium, 2004，第四作者。
7. ZX1 was a pleiotropic mutant isolated from Streptomyces lividans JT 46 by NTG mutagenesis.
ZX1和ZX7是变铅青链霉菌JT46经NTG诱变所产生的多效性突变菌株。
8. PENG Bao-cheng, YE Shun-hua.The mutagenesis and carcinogenic effect of automobile exhaust [J].Overseas Medicine Sanitation Fascicle, 1995,22 ( 3 ): 144-148.
[1]彭宝成,叶舜华.汽车尾气排出物的致突变和致癌效应[J].国外医学卫生学分册,1995,22(3):144-148.
9. A competing theory is that a mutagenesis drug may eradicate a virus or bacterial population by reducing the fitness to negative values.
一个竞争性的理论是诱变药物通过降低对负面价值的适应性而根除病毒或细菌群体。
10. A medicinal chemistry campaign, in conjunction with a chemical mutagenesis program, was thus launched at Merck &Co. to develop (+)- 1 as a novel anti-flea therapeutic agent for companion animals.
一药物化学运动,结合化学诱变节目因此推出与默克公司开发(+)-1作为一种反蚤剂治疗同伴动物.
11. The feasibility of the protoplast mutagenesis for increasing productivity was studied on a Claviceps paspali strain, which was not easy to produce conidia under laboratory conditions.
为了提高在一般条件下不易产生分生孢子的雀稗麦角菌的产碱率,对原生质体诱变育种的条件和方法进行了探讨。
12. So we started doing transposon mutagenesis.
于是我们开始做转座子的突变发生。
13. If Its gene mutagenesis was considered as an important factor, arginine esterase is still safe at the dosage of about 100 times clinical dosage.
从致突变角度考虑，精氨酸酯酶在高于临床治疗剂量约100倍的条件下仍然安全。
14. Natural competence-deficient mutant of Bacillus subtilis BR151, which carries plasmid pUB110, was obtained by nitrosoguanidine mutagenesis on solid medium.
以携带pUB110质粒的枯草芽孢杆菌BR151菌株为出发菌株，利用亚硝基胍作诱变剂，直接在LB平板上进行诱变。
15. The development of space biology and its recent progresses are reviewed with emphasis on space medicine,space bio-engineering and breeding of space mutagenesis.
以载人航天为任务背景的航天医学工程学科在中国载人航天工程中发挥了重要的作用并得到了迅速发展。
16. A Selenium-enriched yeast strain L-11-7-2 was obtained from Saccharomyces cerevisiae L-11 as starting strains by DES mutagenesis and screening on plate containing Na2SeO3 and ethionine.
以酿酒酵母Saccharomyces cerevisiaeL-11为出发菌株,通过DES多次诱变,Na2SeO3和乙硫氨酸抗性平板选择,得到一株高硒和高蛋氨酸含量的菌株L-11-7-2,其蛋氨酸含量达到1.37%,是L-11的169%。
17. In order to improve the optimum temperature of lipases, The Penidilum expansuin lipase (PEL) gene was mutated by site-directed mutagenesis using overlap extension PCR technique.
利用重叠延伸PCR法对扩展青霉碱性脂肪酶(PEL)基因作了体外定点突变，获得了最适作用温度有所提高的突变体。
18. Mutagenesis - selection of Saccharomyces cerevisiae which have the better ability of reducing diacetyl by protoplast mutagenization with UV.
原生质体紫外诱变筛选还原双乙酰能力强的啤酒酵母。
19. Meanwhile,the progression of the corresponding analysis strategies on these transporters is portrayed including site-directed mutagenesis,helix packing and crystallization.
同时总结了对外排蛋白进行结构与功能关系研究的主要的方法,包括定点诱变、螺旋空间排列和结晶等.
20. The Ames test was negative and no mutagenesis was detected in the experiments mentioned above.
在动物体内亦无蓄积毒性作用。 (2 )Ames实验为阴性。
21. Site-directed mutagenesis can correctly change the base sequence and get mutant proteins.
基因定点突变技术可以精确地改变基因的特定碱基序列,获得突变蛋白质。
22. Without theoretical tools like the new model, drug designers looking to create pills to induce lethal mutagenesis couldn't say for certain under what parameter ranges the drugs really worked.
如果没有类似该新模式的理论工具，企图创造出诱发致命性突变药物的设计者就不能确定该药物真正的在哪些参数范围内发挥作用。
23. Oligonucleotide-directed site-specific mutagenesis is previously used routinely to introduce desired mutations into target DNA sequences.
它不仅可以阐明基因表达的调控机理,还可用研究蛋白质结构与功能间的关系,改造天然蛋白质,使之更符合应用需求。
24. It is possible to screen for point mutations in the populations of EMS mutagenesis with high-throughput and low-cost.
它能高通量低成本地在EMS诱变群体中鉴定出发生在特定基因上的点突变。
25. Safe use: not produce any organic chloride and other harmful substances that may lead to carcinogenesis, teratogenesis and mutagenesis, such as THMS and chloroform.
安全：不会产生“三致物质”的有机氯化物和三氯甲烷、氯仿等物质；
26. Site-directed mutagenesis and single-channel patch-clamp recording were used to explore the molecular transitions that underlie inactivation in Shaker potassium channels expressed in Xenopus oocytes.
定点基因突变以及单通道夹被用于探测爪蟾卵细胞中摇动钾离子通道被去活化时的分子转移过程。
27. Moreover, results of the site-directed mutagenesis of a C-repeat/DRE and two APE-like motifs in a promoter-like region (?630/?308) suggested that two APE-like motifs might be essential for transcriptional regulation of the bkt gene.
对其启动子类似区(-630/-308)中两种功能元件的定点突变结果发现 APE-like(蓝光调控元件)对于 bkt 基因自身的转录可能存在影响。
28. The arsenic mutagenesis ,carcino genesis and teratogenesis,and their mech anisms are reviewed.
对砷的致突变、致癌及致畸性及其机制进行分析。
29. Laser Radiation Mutagenesis Used in Thermostability Phytase Screening[J].
引用该论文 彭益强,张燕,庄月娥,方柏山,张文珍.
30. Penicillium expansum PF898, which is a mutant strain by many generation mutagenesis and breeding from the original strain isolated from soil in China, produced an alkaline lipase at a high level.
扩展青霉PF898可产生一种具有重要工业生产价值的碱性脂肪酶，该产生菌是从我国土壤中分离并经多代的诱变育种选育的脂肪酶高产菌株。
31. Insertional mutagenesis is a method for identifying genes by using the integration of DNA as the mutagen,thereby facilitating the cloning of the mutated gene.
插入突变是一种通过外源DNA整合的方式来获得突变体,并克隆得到对应突变基因的方法。
32. Insertional mutagenesis is a method for identifying genes by using the integration of DNA as the mutagen, thereby facilitating the cloning of the mutated gene.
插入突变是一种通过外源DNA整合的方式来获得突变体，并克隆得到对应突变基因的方法。
33. The strategis of large-scale mutagenesis and gene screening include chemical mutagenesis,insertional mutagenesis and gene trap.
摘要 用于大规模基因突变与筛选的主要策略有化学诱变、插入突变、基因诱捕。
34. Abstract Purpose : To explore cigarette end immersion-induced mutagenesis in bone marrow PCE and primary spermatocyte.
摘要 目的:探讨香烟烟蒂水浸泡液对雄性小鼠骨髓细胞和睾丸初级精母细胞的遗传毒作用。
35. Abstract : Dry seeds of two wheat cultivars were carried out for mutagenesis by satellite.The mutagenic effects of SP2 generation in agronomic traits were analyzed.
摘要 ： 利用返回式卫星搭载两个小麦品种（系）种子进行空间诱变处理，对SP2代农艺性状变异效果进行了分析。
36. Chemical mutagenesis breeding is an new method to breed crop varieties by chemical mutagenesis. The principles and its progress in soybean breeding were summerized.
摘要化学诱变育种是通过化学诱变育成农作物品种的新方法。概述了化学诱变的原理及其在大豆育种上的应用进展。
37. The article describes the advances in the research of D-ribose with fermentation. It focuses on the screening of strain and the condition of mutagenesis.
摘要对发酵法生产D-核糖菌种的进展及选育条件等进行研究。
38. The strategies of large-scale mutagenesis and gene screening include chemical mutagenesis, insertional mutagenesis and gene trap.
摘要用于大规模基因突变与筛选的主要策略有化学诱变、插入突变、基因诱捕。
39. Objective To describe the current research progresses achieved in engineering Streptomyces avermectinius through mutagenesis and recombinant DNA technology.
摘要目的综述近年来运用基因工程技术对阿维菌素产生菌改良的研究进展。
40. This paper introduces the principles and characteristics of Magnaporthe grisea mutagenesis induced by physical and chemical inductions and genetic transformation briefly and reviews the research advances of these techniques.
摘要系统地介绍了稻瘟病菌物理诱变、化学诱变和遗传介导突变的原理、特点和研究进展，并评述了它们各自的优缺点。
41. Methods: Glycosylation site was deleted by Asn302-Ala302 mutagenesis using PCR amplification.
方法:使用PCR扩增的方法,将302位天冬酰胺(Asn302)突变为丙氨酸(Ala302),去掉糖基化位点;
42. Methods:Non-glycosylated pro-urokinase was created by Asn302-Ala302 mutagenesis.
方法:将302位天冬酰胺(A sn302)突变为丙氨酸(A la302),构建非糖基化尿激酶原。
43. Methods By using complex mutagenesis of LiCl and ultraviolet rays,we deal with the simple spore suspension.
方法采用氯化锂和紫外线复合诱变单孢子悬浮液。
44. It can inactivate mutagens directly, inhibit the mutagenesis of mutagens on cells and inhibit mutant expression which were preincubated with mutagens.
既可直接灭活致突变物，又可抑制致突变物对细胞的致突变作用，还可抑制已受致突变作用的细胞的突变表达；
45. The principles,operation and applications of site-directed mutagenesis,gene fusion technology,and post-translational modification methods were introd...
最后,对生物功能催化膜的研究方向进行了展望。
46. The prospects of space mutation breeding was described.The space mutagenesis will provided a new way for the future breedin...
最后对未来植物空间诱变育种的应用前景进行了展望,并指出空间诱变技术开创了植物育种的又一新途径。
47. Studies suggest that it probably interacts directly with the viral polymerase, and we want to confirm that by mutagenesis and by enzymatic activity assays," said Tao.
有研究表明，核蛋白可能会和病毒的聚合酶直接发生相互作用，我们将通过人工诱变技术及酶活性测定等技术来核实这一说法。”
48. In order to screening the mutants with higher activities,the mutation breeding of the strain TA-SD was carried out by ultraviolet mutagenesis.
本实验采用紫外诱变法对TA-SD菌株进行诱变育种,筛选高活性的突变株。
49. Insertional mutagenesis using T-DNA, transposons and plasmids axe commonly methods to creating a mutant library. here we summarize these strategies as well as the progress in the functional genomes research.
本文分别介绍三种方法的原理及其在功能基因组学研究中的应用和研究进展。
50. This article elaborately studied Orientational Mutagenesis and breeding of the strain which produced amylase and protease, a high producing cmcase and phytase strain that is named ZQW48.
本文通过对一株淀粉酶及蛋白酶产生菌进行定向诱变选育，筛选出高产纤维素酶和植酸酶的突变株ZQW48。
51. Therefore, based on the T-DNA insertional mutagenesis of M, grisea in our lab, we screened for mutants with stable mut.
本研究在本实验室创建的T-DNA插入突变体库的基础上，筛选性状稳定的致病相关突变体，深入分析突变体的表型，克隆和解析相关基因的生物学功能。
52. In this thesis, Agrobacterium tumefaciens mediated transformation (ATMT) approach was used to screen insertional mutagenesis and the factors that affected efficiency of transformation were optimized.
本研究通过一系列农杆菌介导的转化(Agrobacterium tumefaciens mediated transformation, ATMT)试验，摸清了影响转化效率的主要因素；
53. The study mainly investigated the effects of the mutagenesis, conditions of nutrition and culture on inulinase production by Aspergillus niger.
本论文主要研究了人工诱变、营养条件和培养条件对黑曲霉液体发酵产菊粉酶的影响,并对菊粉酶的酶学性质进行了探索。
54. Genetic site-directed mutagenesis is an important way in studying the relation of proteinic formation and function.
杀虫晶体蛋白的定点突变研究与细菌杀虫剂和转基因植物开发的关系。
55. Kammann M,Laufs J,Schell J,et al.Rapid insertional mutagenesis of DNA by polymerase chain reaction (PCR)[J].Nucleic Acids Res,1989,17(13):5404.
王关林,李大力,方宏筠.蜂毒溶血肽基因的定点诱变及其在大肠杆菌中的表达[J].遗传学报,2000,27(2):176-182.
56. The effects of traditional Chinese medicine CF on the Kunming mice by micronucleus test and monstrous sperm test showed that only negative reaction presented which proved that the CF had no mutagenesis.
用昆明种小白鼠对中药“壮阳促孕散”进行了微核试验、子畸形试验.结果表明:小白鼠微核试验、子畸形试验均呈阴性反应.说明中药“壮阳促孕散”对小白鼠无致突变作用.
57. A dsp (disease specific pathogenicity) mutant,AM11,of Xanthomonas oryzae pv oryzicola (Xooc)was obtained following mutagenesis of the wild type Xooc strain RS105 with diethyl sulfate.
用硫酸二乙酯 (DES)化学诱变水稻条斑病细菌RS1 0 5菌株 ,获得一株dsp基因突变体AM1 1。
58. Nine motility mutants (M43, M49, M143, M330, M432, M451, M574, M725, M726) of Erwinia carotovora subsp. carotovora were obtained by using Tn5 mutagenesis.
用转座子 Tn5对胡萝卜软腐欧氏杆菌胡萝卜亚种 ( Erwinia carotovora subsp.carotovora,Ecc)进行诱变 ,获得 9个游动性改变了的突变体。
59. Transposon Tn5 mutagenesis in a wildtype strain JXO I of Xanthomonas campestris pv. oryzaewas conducted.
用转座子 Tn5诱变水稻白叶枯病菌日本系统小种1菌(?)
60. Objective To evaluate the indeterminate growth mutant of tomato derived by space mutagenesis to provide the basis for selecting and cultivating the molecular markers of tomato growth habit.
目的通过对航天诱变所获得的番茄无限生长习性突变体进行分子水平的鉴定,为番茄生长习性分子标记选育提供依据。
61. Purpose: This paper studies the relationships between Heated Cooking Oil Vapors(HCOV) and Allium Sativum Oil(ASO) in mutagenesis.
目的：为研究油烟凝聚物与肿瘤发生的潜在关系及大蒜油的防护作用。
62. AIM：To explore the potential relationship between nontargeted mutagenesis and the cascades of protein phosphorylation of signal transduction pathways in cells.
目的：初步了解哺乳类细胞非定标性突变形成是否与以蛋白质磷酸化级联反应为主要形式的细胞信号传导通路有关；
63. The principles, operation and applications of site-directed mutagenesis, gene fusion technology, and post-translational modification methods were introduced emphatically.
着重阐述了基因定点突变技术、基因融合技术和翻译修饰技术等新兴定点固定化技术的原理、特点和操作。
64. Protein engineering and site directed mutagenesis have been used to change the active site and alter the substrate specificity of various hydroxynitrile lyases.
研究人员已经利用蛋白质工程和定点突变技术来改变各种醇腈酶的活性位点和底物特异性等。
65. In Vitro Mutagenesis - Alternate Approach to Breeding of Gossypium hirsutum L.
离体诱变一种附加的陆地棉育种方法。
66. The results indicate that acid-producing activity and leaching capability of phosphate of At.t are changed notably for different mutagenesis agents and different mutagenesis time.
结果表明：在不同诱变剂及不同诱变时间的影响下，嗜酸氧化硫硫杆菌产酸活性及对磷矿的浸出能力都发生了显著的改变。
67. The results indicated that space mutagenesis can n ot only improve existing restorers,also create new restorers.
结果说明，空间诱变既可改良现有恢复系，又可创造新恢复系。
68. Conclusion : It is suggested that SP can significantly inhibit the mutagenesis of germ cells and stomatic cells induced by CP.
结论:提示海藻多糖对由环磷酰胺引起的体细胞和生殖细胞的基因突变有着明显的拮抗作用。
69. Conclusion: The method of phenol-sulfuric acid is simple, sensitive, and reliable, Fructus Schisandrae Chinensis polysaccharide has anti mutagenesis.
结论：苯酚-硫酸法简便、灵敏，可用于五味子多糖的测定；五味子多糖具有抗突变性。
70. Some effective measures beneficial to the production of alkaline proteinase are discussed: organismal rejuvenation, mutagenesis breeding. metabolic regulation and improvement of technology condition.
综述了提高碱性蛋白酶生产效益的可能途径：菌种的及时复壮，菌种的诱变选育，菌种的代谢调控选育，工艺条件的控制。
71. Cancer genetics, somatic mutagenesis, DNA repair, genomics and molecular medicine.
肿瘤发生的遗传机制；体细胞突变的发生机制；DNA修复，基因组学与分子医学。
72. The root system of the germinating seed was treated with colchicines(0.1%) to induce peanut(Arachis hypogaea L.) mutagenesis.
花生“皖花4号”种子萌发后,采用0.1%的秋水仙素溶液处理其幼根。
73. Aniline compounds is toxic and may lead to mutagenesis, carcinogenesis or teratogenesis.
苯胺类化合物有毒，有“三致”作用，
74. Induced conchocelis seemly had lower mutation rates.However mutagenesis happened in their F1 thalli widely.The regularity of mutation expression in diploid cells was showed.
虽然经诱变的丝状体在藻丝阶段表现较低的突变率，然而诱变引发的突变却主要在后代配子体中表达，显示为二倍体细胞的突变表达规律。
75. Many research groups successfully rely on whole-gene random mutagenesis and recombination approaches for the directed evolution of enzymes.
许多研究小组利用整基因随机突变形成和重组方法,已成功的进行了酶的定向进化。
76. High pressure will be a new physical mutagenesis breeding measure, possessing some excellences of easy-doing、no pollution and higher mutation rate.
超高压可望作为一种新型的物理诱变育种手段，具有操作简便、无污染，突变率高等优点。
77. The use of retrovirus-mediated insertional mutagenesis in zebrafish has led to the mutation and rapid identification of hundreds of genes required for embryonic development and cell growth.
运用反转录病毒介杂的插入突变技术，在脊椎动物斑马鱼中已经获得了许多影响胚胎发育和细胞生长过程的突变体，并找到了对应的基因。
78. This method facilitates increasing the efficiency of induced mutagenesis in breeding and provides a new way to study the mechanisms of mutation formation in UV irradiated Streptomyces sp. cells.
这一方法能较大幅度提高链霉菌紫外诱变育种的工作效率，同时也为链霉菌经紫外诱变后突变形成机制的进一步研究提供了新途径。
79. The whole system is likely to make zebrafish the first vertebrate to achieve saturation mutagenesis and gene screening.
这套系统的建立使斑马鱼成为第一个有可能达到基因饮和突变和筛选的脊椎动物。
80. The compound alkylates certain DNA bases, leading to mutagenesis.
这种化合物通过烷基化特定的DNA碱基而导致突变发生。
