proinsulin

proinsulin

1. Keywords type 2 diabetes mellitus;the first kindred;insulin;proinsulin;

2型糖尿病;一级亲属;胰岛素;胰岛素原;

2. Proinsulin immunoreactivity (PIM)in type 2 diabetes mellitus

2型糖尿病患者血浆前胰岛素水平

3. Study on the proinsulin secretion after arginine stimulation test and its relationship with plasma glucose level in type 2 diabetes

2型糖尿病精氨酸刺激后胰岛素原的释放及其与血糖的关系

4. The association between fasting serum leptin and specific insulin, proinsulin and insulin sensitivity in different glucose tolerance individuals

不同糖耐量个体血清瘦素水平与特异胰岛素、胰岛素原及胰岛素敏感性的关系探讨

5. Keywords Human proinsulin;Escherichia coli;Expression;

人胰岛素原;大肠杆菌;表达;

6. proinsulin human

人胰岛素原<降血糖药>

7. Expression and Purification of Proinsulin C-peptide and its Cell Bioactivity

人胰岛素原C肽的表达、纯化及其细胞活性研究

8. Keywords human proinsulin gene;retroviral vector;gene recombination;gene expression;

人胰岛素原基因;逆转录病毒载体;基因重组;基因表达;

9. Construction and identification of recombinant defective retroviral vector with mutant human proinsulin gene and stable virus-producing cell lines

人胰岛素原突变体重组逆转录病毒及稳定包装细胞系的构建和鉴定

10. Construction and Expression of the Gene for Human Proinsulin Analog(B-Arg-Arg-A)

人胰岛素原类似物（B－Arg－Arg－A）基因的构建和表达

11. It showed 78.08% radio immuno activity (RIA), but only about 5.2% of receptor binding activity (RBA) as compared with Met-human proinsulin (Met-HPI) which was prepared in the same way.

以同样方法获得的Met-人胰岛素原(Met-HPI)为对照，研究了其理化性质和生物活性的变化，结果表明，Mut-HPI保留了大部分放射免疫活性，而受体结合活性却只有Met-HPI的5.2%。

12. immunoreactive proinsulin

免疫反应性胰岛素原

13. Keywords coronary heart disease;proinsulin;insulin resistance;ang iotensin I converting enzyme;gene;

关键词冠心病;胰岛素原;胰岛素抵抗;血管紧张素转换酶;基因;

14. Keywords Cardiovascular disease;Risk factors;Epidemiology;Insulin resistance;True insulin;Proinsulin;Coronary angiography;Sleep apnoea syndrome;

关键词心血管疾病;危险因素;流行病学;胰岛素抵抗;真胰岛素;胰岛素原;冠状动脉造影;睡眠呼吸暂停综合征;

15. Keywords impaired glucose tolerance;proinsulin;true insulin;

关键词糖耐量减低;胰岛素原;真胰岛素;

16. Keywords coronary heart disease;insulin resistance;true insulin;proinsulin;dyslipidemia;

冠心病;胰岛素抗药性（胰岛素抵抗）;真胰岛素;胰岛素原;血脂异常;

17. CLINICAL STUDY OF THE RELATIONSHIP BETWEEN ACE GENE POLYMORPHISM AND PROINSULIN, INSULIN RESISTANCE IN PATIENTS WITH CORONARY HEART DISEASE

冠心病患者胰岛素原水平、胰岛素抵抗与血管紧张素转换酶基因多态性关系的研究

18. Construction and Expression of the Gene for Des-terpeptide of C-terminal Human Proinsulin

去B链羧端三肽人胰岛素原的基因构建和表达

19. Keywords Rehmannia glutinosa Libosch water extraction;Type 2 diabetes Mellitus（2-DM）;Proinsulin;Gene expression;

地黄水提液;2型糖尿病;胰岛素原;基因表达;

20. Construction of a mutant human proinsulin gene with signal peptide code and detection of its expression in COS-7 cells

带信号肽人胰岛素原突变体的构建及在COS-7细胞中的表达

21. Abstracts Objective: To investigate the changes of proinsulin and its relationship to insulin resistance in obese subjects.

摘要 目的 研究肥胖患者中胰岛素原水平的变化及其与胰岛素抵抗的关系。

22. Objective To explore the relation between the levels of serum true insulin (TI), proinsulin (PI) levels in patients with coronary heart disease (CHD) and other cardiovascular risk factors.

摘要目的探讨冠心病(CHD)患者血清真胰岛素(TI)、胰岛素原(PI)水平，并分析其与CHD危险因子的关系。

23. Methods:Radio immune assay (RIA) was used to examine total proinsulin immunoreactivity (PIM), immune reactive insulin (IRI) and C peptide (CP) in patients with type 2 diabetes mellitus (DM) and control subjects.

方法 :采用放射免疫分析法测定 2型糖尿病患者和正常对照组血浆前胰岛素 (PIM)、胰岛素 (IRI)和 C肽 (CP)水平。

24. porcine proinsulin

猪原胰岛素

25. Keywords Hyperthyroid;Proinsulin;Insulin;Blood glucose;

甲亢;胰岛素原;胰岛素;血糖;

26. Objective To study the changes and their significance of serum true insulin (TI)and proinsulin (PI) in obese > impaired glucose tolerance (IGT) and type 2 diabetic patients(2-DM).

目的 了解血清真胰岛素(TI)和前胰岛素(PI)在肥胖症、糖耐量减退症(IGT)、2型糖尿病(2-DM)患者中的改变，探讨其在评价胰岛B细胞分泌功能和胰岛素抵抗状态中的价值。

27. AIM:To explore the recombined human proinsulin gene containing glucose reaction element(GLRE) expression in transfected CBRH7919 cells.

目的:探讨含有葡萄糖反应元件的重组人胰岛素原基因在培养的大鼠肝癌细胞中基因转移及表达情况。

28. Objective To determine serum true insulin (TI) and proinsulin (PI) levels in patients with coronary heart disease (CHD), and to explore the relationships of them to other cardiovascular risk factors.

目的探讨冠心病(CHD)患者血清真胰岛素(TI)、胰岛素原(PI)水平，并分析这二者与其他CHD危险因子的关系。

29. Objective To explore the relationship between specific insulin, proinsulin and sleep snoring.

目的研究真胰岛素、胰岛素原与睡眠打鼾的关系。

30. Keywords Diabetes mellitus;type 2;First-degree relatives;First-phase of insulin secretion;Proinsulin;True insulin;Immunoreactive insulin;

糖尿病;2型;一级亲属;胰岛素分泌第一时相;胰岛素原;真胰岛素;免疫活性胰岛素;

31. Keywords diabetes mellitus;proinsulin gene;gene therapy;intramuscular injection;naked plasmid;

糖尿病;胰岛素原基因;基因治疗;肌肉注射;裸质粒;

32. Keywords Diabetes mellitus;mellitus;True insulin;proinsulin;Laboratory techniques and procedures;

糖尿病;非胰岛素依赖型;真胰岛素;胰岛素原;实验室技术和方法;

33. Keywords Type 2 diabetes mellitus;Arginine;Proinsulin;

糖尿病;非胰岛素依赖型;精氨酸;胰岛素原;

34. Gene therapy for diabetes mellitus: construction and identification of eukaryotic cell expression plasmid in rat proinsulin gene

糖尿病的基因治疗技术:大鼠胰岛素原基因真核细胞表达质粒构建与鉴定

35. Conclusions: Fasting serum proinsulin level increased in obese subjects.It further increased in obese with impaired glucose tolerance and diabetes.

结论 空腹血清胰岛素原水平在肥胖患者中异常升高，在伴有糖耐量异常或糖尿病的肥胖患者中，胰岛素原水平进一步升高。

36. Conclusion Nondiabetic patients with CHD have hyperinsulinemia and insulin resistance and there is an independent association between proinsulin and dyslipidemia.

结论CHD患者有高胰岛素血症和胰岛素抵抗状态，TI、PI分别与血糖、血脂等CHD危险因子呈群聚关系。

37. Conclusion Naked plasmid with mutant human proinsulin gene is successfully transfected into diabetic mice, which show the singificant short-term effect of decreasing blood glucose.

结论含有人胰岛素原突变基因的裸质粒成功转染糖尿病小鼠,并有显著的短期降血糖效应。

38. Keywords procarboxypeptidase B;carboxypeptidase B;fusion expression;purification;proinsulin C-peptide;

羧肽酶原B;羧肽酶B;融合表达;分离纯化;胰岛素原C肽;

39. The changes in the plasma true insulin and proinsulin level and its significance to obese, impaired glucose tolerance and type 2 diabetic patients

肥胖症、糖耐量减退、2型糖尿病的真胰岛素和前胰岛素水平的变化及其意义

40. Plasma true insulin and proinsulin in obese and newly diagnosed type 2 diabetic patients

肥胖症患者和新诊断的2型糖尿病患者真胰岛素和前胰岛素的改变

41. Keywords Proinsulin;Analog;Human Proinsulin;Recombination;

胰岛素原;类似物;人胰岛素原;重组;

42. Keywords Proinsulin;Insulin;Sulphonylurea compounds;

胰岛素原;胰岛素;磺脲类药;

43. Keywords proinsulin;mutagenesis;site-directed;vector;retroviral;packaging cell lines;

胰岛素原;诱变;定点;载体;逆转录病毒;包装细胞系;

44. Proinsulin C-peptide

胰岛素原C肽

45. proinsulin gene

胰岛素原基因

46. proinsulin family

胰岛素原家族

47. Proinsulin is a major autoantigen in the disease process， but other autoantigens are likely involved.

胰岛素原是疾病进展过程中的主要抗原，然而其它自身抗原也可能参与其中。

48. Proinsulin was an independent affective factor of insulin resistance.

胰岛素原水平是胰岛素抵抗的独立相关因素。

49. Proinsulin measurement

胰岛素原测量

50. The relationship between serum leptin, proinsulin, true insulin levels and insulin resistance in non-diabetic subjects: a population-based study

血清瘦素水平与胰岛素原、真胰岛素及胰岛素敏感性的关系

51. Serum true insulin, proinsulin determination and their significances in insulin resistance

血清真胰岛素、胰岛素原检测在胰岛素抵抗中的应用

52. Association of Fasting Serum Insulin, Proinsulin and Leptin Levels with Hypertension in Over-weight or Obese Subjects

超重及肥胖高血压患者空腹胰岛素、胰岛素原、瘦素水平与高血压的关系

53. Keywords Hypertensive patients;True insulin;Proinsulin;Perindopril;

高血压病;真胰岛素;胰岛素原;培哚普利;

54. The Level of True Insulin and Proinsulin in Hypertensive Patients and The Therapeutic Effect of Perindopril

高血压病患者真胰岛素、胰岛素原水平及培哚普利干预的影响

55. The plasma levels of proinsulin and true insulin and the effects of ramipril in hypertension

高血压病患者血浆胰岛素原和真胰岛素水平及雷米普利干预的影响

56. (His) 6 - Arg - Arg - human proinsulin

（His）6-Arg-Arg-人胰岛素原